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Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population

NCT06984510 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 2720

Last updated 2025-06-04

No results posted yet for this study

Summary

The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by calculating phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge), and homeostatic dysregulation (HDAge). To examine the association of biological ageing with the risk of T2DM, cox regression models were conducted. Furthermore, we applied survival analysis, restricted cubic spline models and population attributable fraction (PAF) to further evaluate the association between biological ageing and T2DM incidence.

Conditions

  • Type 2 Diabetes Mellitus (T2DM)
  • Metabolic Dysfunction-Associated Steatotic Liver Disease
  • Biological Age

Interventions

OTHER

Observational

Observational

Sponsors & Collaborators

  • Ningbo No. 1 Hospital

    lead OTHER

Eligibility

Min Age
20 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06984510 on ClinicalTrials.gov