A Phase Ib Study of the Selective PKC-β Inhibitor MS-553 in Patients With Refractory or Relapsed CLL/SLL
NCT06979076 · Status: NOT_YET_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 12
Last updated 2025-09-29
Summary
A Phase Ib Study of the Selective PKC-β Inhibitor MS-553 in Patients with Refractory or Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Conditions
- CLL (Chronic Lymphocytic Leukemia)
- SLL (Small Lymphocytic Lymphoma)
Interventions
- DRUG
-
MS-553, DS1
Oral, Dose Schedule 1
- DRUG
-
MS-553, DS2
Oral, Dose Schedule 2
Sponsors & Collaborators
-
MingSight Pharmaceuticals, Inc
lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-07-31
- Primary Completion
- 2028-09-30
- Completion
- 2028-12-31
- FDA Drug
- Yes
More Related Trials
-
Revlimid in Patients With Acute Myelogenous Leukemia and Myelodysplastic Syndrome
NCT00360672 ·Status: COMPLETED ·Phase: PHASE2
-
Dose-escalation Study of Oral Administration of S 55746 in Patients With Chronic Lymphocytic Leukaemia and B-Cell Non-Hodgkin Lymphoma
NCT02920697 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
NCT01578707 ·Status: COMPLETED ·Phase: PHASE3
-
Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML
NCT06533761 ·Status: RECRUITING ·Phase: PHASE1
-
Study of MP0533 in Patients Acute Myeloid Leukemia or Myelodysplastic Syndrome
NCT05673057 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
LP-168 and Obinutuzumab for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Variants of This
NCT06978088 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic Malignancies
NCT05665530 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.
NCT04771572 ·Status: RECRUITING ·Phase: PHASE1
-
Efficacy Study of Revlimid® and Low Dose Continuously Administered Melphalan to Treat High Risk MDS
NCT00744536 ·Status: COMPLETED ·Phase: PHASE2
-
MRD Guided Sonrotoclax and Zanubrutinib in Newly Diagnosed CLL/SLL
NCT06367374 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Safety and Tolerability Study of SNS01-T in Relapsed or Refractory B Cell Malignancies (Multiple Myeloma, B Cell Lymphoma, or Plasma Cell Leukemia (PCL)
NCT01435720 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Study of BGB-11417 in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT05479994 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT06973187 ·Status: RECRUITING ·Phase: PHASE3
-
A Study to Evaluate the Safety and Tolerability of BMS-986403 in Participants With Relapsed and/or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT05244070 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of Ibrutinib + Obinutuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
NCT02537613 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Zanubrutinib, Obinutuzumab, and Sonrotoclax in Previously Untreated Patients With CLL or SLL
NCT06849713 ·Status: RECRUITING ·Phase: PHASE2
-
Study Evaluating Inotuzumab Ozogamicin In Acute Lymphocytic Leukemia
NCT01363297 ·Status: COMPLETED ·Phase: PHASE2
-
Trial of Sirolimus and Methotrexate in Relapsed/Refractory Lymphoblastic Leukemia and Lymphoma
NCT01162551 ·Status: COMPLETED ·Phase: PHASE2
-
First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
NCT04067336 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of CC-96191 in Participants With Relapsed or Refractory Acute Myeloid Leukemia
NCT04789655 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase I Study of MGCD0103 Given Twice Weekly in Patients With Leukemia or Myelodysplastic Syndromes
NCT00324194 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase II Study of MGCD0103 (MG-0103) in Patients With Refractory Chronic Lymphocytic Leukemia
NCT00431873 ·Status: COMPLETED ·Phase: PHASE2
-
Ofatumumab and Dinaciclib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-Cell Prolymphocytic Leukemia
NCT01515176 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
NCT04215809 ·Status: RECRUITING ·Phase: PHASE1
-
Pharmacokinetics (PK), Pharmacodynamics (PD), Safety, Tolerability of Multiple Dose Regimens of MT-3724 for the Treatment of Patients With Relapsed Chronic B-cell Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT02556346 ·Status: WITHDRAWN ·Phase: PHASE1