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Breastmilk Composition and Microbial Profile in the Growth and Development of Healthy Term-born Infants

NCT06970535 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2025-05-14

No results posted yet for this study

Summary

An increasing number of children are developing non-communicable diseases that carry immediate and long-term significant societal and economic impacts. Thus, its prevention is imperative with early interventions, such as those that may fall within the first 1000 days, likely to yield better outcomes. The first 1000 days of life represent a period of rapid development sensitive to influences that may be leveraged to promote healthy growth. Breastfeeding is one such modifiable factor. Observational studies have shown that breastfeeding may be associated with reductions in chronic conditions, though its mechanism remains unknown. The complexity of these relationships is furthered by studies showing maternal metabolic status may alter breastmilk composition. Accordingly, this study aims to evaluate the influence of maternal metabolic status on breastmilk composition and assess associations between breastmilk composition and common noncommunicable diseases in childhood.

Conditions

  • Breastmilk Collection
  • Childhood Obesity
  • Childhood Asthma
  • Allergy

Sponsors & Collaborators

  • Unity Health

    collaborator OTHER

  • University of Toronto

    collaborator OTHER

  • The Hospital for Sick Children

    lead OTHER

Principal Investigators

  • Deborah L O'Connor, PhD, RD · The Hospital for Sick Children

  • Catherine Birken, MD,MSc,FRCPC · The Hospital for Sick Children

  • Jonathon Maguire, MD,MSc,FRCPC · Unity Health Toronto

Eligibility

Min Age
2 Months
Max Age
4 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-15
Primary Completion
2026-01-11
Completion
2026-01-11

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06970535 on ClinicalTrials.gov