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Hydrogen-Rich Water and Metabolic Health in Adults: A 12-Week Randomized Trial

NCT06968715 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-12-22

No results posted yet for this study

Summary

The HYDRO-RESPOND trial is a 12-week randomized controlled study investigating the effects of daily hydrogen-rich water (HRW) consumption on body composition and metabolic biomarkers in adults diagnosed with metabolic syndrome. The study also explores whether individual differences in baseline breath hydrogen levels influence response to HRW. Participants are randomly assigned to receive either HRW or a placebo, with outcomes including changes in body fat, waist circumference, glucose metabolism, lipid profiles, and inflammatory markers. The trial aims to determine the therapeutic potential of HRW and identify predictors of individual responsiveness.

Conditions

  • Metabolic Syndrome

Interventions

DIETARY_SUPPLEMENT

Experimental 1: low-breath hydrogen

Hydrogen-rich water (1.0 L/day)

DIETARY_SUPPLEMENT

Experimental 2: high-breath hydrogen

Hydrogen-rich water (1.0 L/day)

DIETARY_SUPPLEMENT

Experimental 3: low-breath hydrogen

Placebo water (1.0 L/day)

DIETARY_SUPPLEMENT

Experimental 4: high-breath hydrogen

Placebo water (1.0 L/day)

Sponsors & Collaborators

  • University of Novi Sad, Faculty of Sport and Physical Education

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2025-10-30
Completion
2025-11-30

Countries

  • Serbia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06968715 on ClinicalTrials.gov