Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
NCT06968689 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2026-03-02
Summary
The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alternating Current Stimulation (tACS), sham and Transcranial random noise stimulation (tRNS)
Conditions
Interventions
- DEVICE
-
transcranial alternating current stimulation (tACS)
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
- DEVICE
-
Sham
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
- DEVICE
-
transcranial random noise stimulation (tRNS)
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
Sponsors & Collaborators
-
National Institute of Neurological Disorders and Stroke (NINDS)
collaborator NIH -
The University of Texas Health Science Center, Houston
lead OTHER
Principal Investigators
-
Wen Li, PhD · The University of Texas Health Science Center, Houston
Study Design
- Allocation
- RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- QUADRUPLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Max Age
- 60 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2025-06-01
- Primary Completion
- 2027-12-31
- Completion
- 2028-02-29
- FDA Device
- Yes
Countries
- United States
Study Locations
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