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Assessment of Health Effects of Air Purifier Interventions on Chronic Kidney Disease Patients

NCT06963372 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2025-05-09

No results posted yet for this study

Summary

This exploratory study investigates the impact of indoor air quality improvement via air purifiers on the health of chronic kidney disease (CKD) patients.

A randomized, single-blind, crossover study with 24 CKD patients and 24 healthy controls was conducted at two hospitals. Participants used either a true filter or a sham filter in air purifiers for four weeks each, with a two-week washout period. True filters significantly reduced indoor PM2.5 levels compared to sham filters. Higher indoor PM2.5 levels were associated with increased cytokines (IL-1beta, IL-6, IL-8/CXCL8) and decreased hemoglobin, with ESR and PWV showing an increasing trend, particularly in CKD patients. True filters significantly reduced IL-1beta and IL-8/CXCL8 levels, with a borderline significant reduction in ABI. The study confirmed limited but notable effects of air purifiers on reducing PM2.5 and improving some health markers in CKD patients.

Conditions

  • Chronic Kidney Diseases
  • Particulate Matter

Interventions

DEVICE

True filter (4w) → Washout (2w) → Sham filter (4w)

Used a true filter for 4 weeks, followed by a 2-week washout, then used a sham filter for 4 weeks.

DEVICE

Sham filter (4w) → Washout (2w) → True filter (4w)

Used a sham filter for 4 weeks, followed by a 2-week washout, then used a true filter for 4 weeks.

Sponsors & Collaborators

  • Inha University Hospital

    lead OTHER

Principal Investigators

  • Hwan-Cheol Kim · Inha University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-04-11
Primary Completion
2022-11-01
Completion
2022-12-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06963372 on ClinicalTrials.gov