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A Targeted Amino Acid Supplement for People With Parkinson's Disease

NCT06954662 · Status: ACTIVE_NOT_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2025-07-14

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if an amino acid supplement that is specifically made for people with Parkinson disease can improve nutrition without interfering with dopamine medication in people living with Parkinson disease. The main question it aims to answer is:

• Does an amino acid supplement that is specifically made for people with Parkinson disease have short-term improvements in nutrition deficiencies, while minimally interfering with Parkinson disease medication?

Researchers will compare the short-term effects of this specialized nutrition supplement to a supplement that is available for everyone to purchase in a store (whey protein supplement-a milk by-product) and to an inactive supplement. Researchers will then check for the indicators of nutrition levels and the presence of dopamine medication in the blood. Researchers will also assess mood and movement abilities in participants.

Participants will be asked to:

* attend 4 study visits over the course of 4 weeks (initial orientation visit plus 3 intervention visits).
* drink one of the 3 supplements (supplements will be mixed into water to create a beverage) at each of the 3 intervention visits.

* participate in blood drawings and mood and movement assessments at each of the intervention visits.
* engage in a phone call after each intervention visit to determine any delayed responses.

Conditions

  • Parkinson Disease, Idiopathic

Interventions

DRUG

Amino acid supplement

a targeted amino acid supplement designed to provide dietary nutrients that are commonly deficient in people with PD while minimizing interference with L-Dopa medication

DIETARY_SUPPLEMENT

Whey Protein Supplement

Whey protein is one of the primary proteins found in all dairy products. It is a complete protein as it contains all the essential amino acids. We will use a 20 gram dose.

DIETARY_SUPPLEMENT

Isonitrogenous Placebo Supplement

The control supplement used in this study is an isonitrogenous placebo beverage. This supplement will consist of an inert amino acid (alanine) with the same amino acid load as the whey protein and the targeted amino acid supplement (16.2 grams).

Sponsors & Collaborators

  • UConn Health

    lead OTHER

Principal Investigators

  • Cristina Colon-Semenza, PT, MPT, PhD · University of Connecticut

  • Jacob Earp, PhD · University of Connecticut

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-22
Primary Completion
2025-09-30
Completion
2025-09-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06954662 on ClinicalTrials.gov