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Reproductive Outcomes After Intracytoplasmic Sperm Injection (ICSI) With Surgically Retrieved Sperm.

NCT06951061 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200000

Last updated 2025-04-30

No results posted yet for this study

Summary

This research project explores how the source of sperm affects outcomes in assisted reproductive technologies (ART), focusing on children conceived through intracytoplasmic sperm injection (ICSI) with surgically retrieved sperm (SRS). Outcomes will be compared to those from ICSI with ejaculated sperm and conventional IVF. Using national registry data from all IVF and ICSI treatments in Sweden between 2007 and 2023 (Q-IVF), the study applies artificial intelligence (AI) and machine learning (ML) to identify factors influencing success rates. The aim is to improve prediction models and support more personalized fertility treatments. Special emphasis is placed on understanding the potential risks and long-term health outcomes for children conceived using SRS, which may be associated with higher rates of genetic abnormalities. The results may help optimize care strategies for infertile couples.

Conditions

  • Reproductive Technology, Assisted
  • IVF Outcomes
  • ICSI

Interventions

PROCEDURE

IVF/ICSI

In vitro fertilization with or without ICSI with ejaculated and surgically retrieved sperm.

Sponsors & Collaborators

  • Göteborg University

    collaborator OTHER

  • Uppsala University

    collaborator OTHER

  • Karolinska Institutet

    lead OTHER

Principal Investigators

  • Panagiotis Tsiartas, Associate Professor · Karolinska Institutet

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-01-01
Primary Completion
2023-12-31
Completion
2027-05-30

Countries

  • Sweden

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06951061 on ClinicalTrials.gov