Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)
NCT06938971 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150
Last updated 2026-05-13
Summary
The primary objective of this trial is to compare the effects of 18 weeks structured exercise training versus on control on healt-related quality of life in patients with mCRC undergoing first-line chemotherapy.
Conditions
- Metastatic Colorectal Cancer (mCRC)
Interventions
- OTHER
-
Exercise training
Participants allocated to the exercise intervention group will receive standard care plus an exercise intervention. The exercise intervention will consist moderate-to-high intensity supervised and unsupervised home-based exercise training (bicyling, walking, or running) 5 times/week for 18 weeks.
Sponsors & Collaborators
-
Rigshospitalet, Denmark
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- SUPPORTIVE_CARE
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-05-16
- Primary Completion
- 2027-05-01
- Completion
- 2030-05-01
Countries
- Denmark
Study Locations
More Related Trials
-
Resilience and Equity in Aging, Cancer, and Health (REACH)
NCT04674267 ·Status: RECRUITING ·Phase: NA
-
Exercise Training for Rectal Cancer Patients
NCT02538913 ·Status: TERMINATED ·Phase: NA
-
Assessment of Fitness After Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients
NCT01334593 ·Status: COMPLETED
-
Local Excision of Clinical T3 Rectal Adenocarcinoma Showing Major Response(ycT0-1) After Neoadjuvant Chemoradiotherapy
NCT02490709 ·Status: UNKNOWN ·Phase: PHASE2
-
Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing
NCT00833508 ·Status: COMPLETED ·Phase: NA
-
Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Trial
NCT06524362 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Normobaric Oxygen Therapy in Colorectal Cancer Patients
NCT06946004 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Microwave Ablation Versus Stereotactic Body Radiotherapy for Colorectal Liver Metastases in Oligometastatic Disease: a Prospective, Randomised, Phase 2 Trial
NCT03654131 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Sarcopenia and Multimodal Rehabilitation on the Prognosis of Rectal Cancer Patients Receiving CCRT
NCT05664607 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer
NCT05914766 ·Status: RECRUITING ·Phase: NA
-
Multidimensional Rehabilitation Intervention in Colorectal Cancer Survivors - a Pilot Study
NCT05957289 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Curative Chemoradiation of Low Rectal Cancer
NCT02438839 ·Status: ACTIVE_NOT_RECRUITING
-
Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer
NCT03573791 ·Status: RECRUITING
-
Personalized Dietary Intervention in Managing Bowel Dysfunction and Improving Quality of Life in Stage I-III Rectosigmoid Cancer Survivors
NCT03063918 ·Status: COMPLETED ·Phase: NA
-
Relationship Between Quality of Life, Treatment Modalities, and Patient Treatment/Outcome Expectations
NCT00648635 ·Status: ACTIVE_NOT_RECRUITING
-
Self-Management Survivorship Care in Stage I-III Non-small Cell Lung Cancer or Colorectal Cancer
NCT04428905 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
SBRT Combined With CAPEOX, Bevacizumab, and PD-1 Inhibitor for the Treatment of RAS-Mutant, MSS-Type, Unresectable Metastatic Colorectal Cancer.
NCT06835179 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Local Liver Treatment for Multi-organ Colorectal Cancer Metastases
NCT06449937 ·Status: RECRUITING ·Phase: NA
-
Exploratory Study of Intermittent Hypoxia Intervention on Colorectal Cancer
NCT06584318 ·Status: RECRUITING ·Phase: NA
-
The Effects of a 9 Week Exercise Programme on Fitness and Quality of Life in Rectal Cancer Patients After Chemoradiotherapy and Before Surgery
NCT01914068 ·Status: COMPLETED ·Phase: NA
-
Short Course Radiotherapy, Unresectable Rectal Cancer, Liver Metastasis
NCT03022734 ·Status: UNKNOWN ·Phase: PHASE2
-
Single-port Robotic Transanal Total Mesorectal Excision
NCT06591572 ·Status: COMPLETED ·Phase: NA
-
Tumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer
NCT06949098 ·Status: RECRUITING ·Phase: PHASE2
-
Effect of Meal Timing During Cancer Treatment in Patients in Alaska: A Randomized Clinical Trial
NCT06802172 ·Status: RECRUITING ·Phase: NA
-
The Effect of ePRO on Quality of Life and Prognosis of Patients With Unresectable Metastatic Colorectal Cancer
NCT04684095 ·Status: UNKNOWN ·Phase: NA