XS-03 in Combination With FOLFOX or FOLFIRI and Bevacizumab for Treatment of Metastatic Colorectal Cancer Patients With RAS Mutation
NCT06936527 · Status: ENROLLING_BY_INVITATION · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 102
Last updated 2025-09-03
Summary
XS-03 in combination with FOLFOX or FOLFIRI and Bevacizumab for treatment of metastatic colorectal cancer patients with RAS mutation
Conditions
- Colorectal Cancer
- Metastatic Colorectal Cancer With RAS Mutation
Interventions
- BIOLOGICAL
-
Drug: XS-03, Biological: Bevacizumab, Drug: FOLFOX, Drug: FOLFIRI
XS-03 orally Bevacizumab intravenously FOLFOX intravenously FOLFIRI intravenously
- BIOLOGICAL
-
Drug: XS-03
XS-03 orally
- BIOLOGICAL
-
Biological: Bevacizumab, Drug: FOLFOX, Drug: FOLFIRI
Bevacizumab intravenously FOLFOX intravenously FOLFIRI intravenously
Sponsors & Collaborators
-
NovaOnco Therapeutics Co., Ltd.
lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-05-23
- Primary Completion
- 2028-04-30
- Completion
- 2028-07-30
Countries
- China
Study Locations
More Related Trials
-
Nivolumab Plus FOLFOXIRI/Bevacizumab in First Line Chemotherapy of Advanced Colorectal Cancer RASm/BRAFm Patients
NCT04072198 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Bevacizumab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer
NCT00719797 ·Status: COMPLETED ·Phase: PHASE3
-
Study of 5-Fluorouracil/Leucovorin/Oxaliplatin (FOLFOX) + Bevacizumab Versus 5-Fluorouracil/Leucovorin/Oxaliplatin/Irinotecan (FOLFOXIRI) + Bevacizumab as First Line Treatment of Patients With Metastatic Colorectal Cancer Not Previously Treated and With Three or More Circulating Tumoral Cells
NCT01640405 ·Status: COMPLETED ·Phase: PHASE3
-
First-line FOLFOXIRI Plus Bevacizumab in BRAF Mutant Metastatic Colorectal Cancer
NCT01437618 ·Status: COMPLETED
-
CMAB009 Combined With FOLFIRI First-line Treatment in Patients With RAS/BRAF Wild-type, Metastatic Colorectal Cancer
NCT03206151 ·Status: COMPLETED ·Phase: PHASE3
-
A Multicenter, Clinical Study of FOLFOXIRI With Bevacizumab As First-line Therapy in Patients With mCRC
NCT02246049 ·Status: COMPLETED ·Phase: PHASE2
-
A Study Comparing the Efficacy and Safety of Vanucizumab and FOLFOX With Bevacizumab and FOLFOX in Participants With Untreated Metastatic Colorectal Cancer
NCT02141295 ·Status: TERMINATED ·Phase: PHASE2
-
Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation
NCT03671252 ·Status: RECRUITING ·Phase: PHASE3
-
Sequential and Concurrent FOLFOXIRI/Bevacizumab Regimens Versus FOLFOX/Bevacizumab in First-Line Metastatic Colorectal Cancer
NCT01765582 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase II/III Study of HR070803 in Combination With Oxaliplatin, 5-fluorouracil, Calcium Folinate and Bevacizumab Versus FOLFOX in Combination With Bevacizumab for First-line Treatment of Advanced Colorectal Cancer
NCT05945901 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
FOLFOXIRI Plus Bevacizumab With or Without Atezolizumab as 1st Line Treatment of pMMR and IS IC-High Metastatic Colorectal Cancer Patients.
NCT06733038 ·Status: RECRUITING ·Phase: PHASE3
-
FOLFOXIRI for Neoadjuvant Treatment of High-risk Locally Advanced Colorectal Cancer
NCT05018182 ·Status: UNKNOWN ·Phase: PHASE2
-
Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colorectal Cancer
NCT01270438 ·Status: WITHDRAWN ·Phase: PHASE2
-
Second Line ColoRectal Cancer Therapy in Combination With Combination of FOL- Folinic Acid(Leucovorin), F - Fluorouracil and OX - Oxaliplatin (FOLFOX)
NCT00278889 ·Status: COMPLETED ·Phase: PHASE2
-
Second-line FOLFOX With or Without Regorafenib in mCRC Patients Failed to First-line Irinotecan Plus Fluoropyrimidines
NCT01786538 ·Status: WITHDRAWN ·Phase: PHASE3
-
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
NCT06662786 ·Status: RECRUITING ·Phase: PHASE3
-
FOLFOXIRI + Bev + Atezo vs FOLFOXIRI + Bev as First-line Treatment of Unresectable Metastatic Colorectal Cancer Patients
NCT03721653 ·Status: COMPLETED ·Phase: PHASE2
-
First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX
NCT00384176 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Influence of BRAF and PIK3K Status on the Efficacy of 5-Fluorouracil/Leucovorin/Oxaliplatin (FOLFIRI) Plus Bevacizumab or Cetuximab in Patients With RAS Wild-type Metastatic Colorectal Carcinoma and < 3 Circulating Tumor Cells (CTC)
NCT01640444 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
NCT06750094 ·Status: RECRUITING ·Phase: PHASE3
-
Neoadjuvant FOLFOXIRI Chemotherapy in Resectable Liver Metastasis of Colorectal Cancer
NCT03487939 ·Status: UNKNOWN ·Phase: PHASE2
-
FOLFOXIRI Plus Cetuximab vs. FOLFOXIRI Plus Bevacizumab 1st-line in BRAF-mutated mCRC
NCT04034459 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Folfoxiri Plus Bev Followed by Reintroduction of Folfoxiri Plus Bev at Progression Versus Folfox Plus Bev Followed by Folfiri Plus Bev in mCRC
NCT02339116 ·Status: UNKNOWN ·Phase: PHASE3
-
Trial Comparing Two Two Sequences of Therapy in Colorectal Metastatic Patients
NCT01030042 ·Status: COMPLETED ·Phase: PHASE3
-
FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients
NCT05727163 ·Status: RECRUITING ·Phase: PHASE2