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The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial

NCT06929364 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-04-16

No results posted yet for this study

Summary

ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis. The aim of this clinical trial is to determine whether probiotic treatment can significantly modulate gut microbiome composition and functionality in endometriosis patients, specifically parameters associated with the estrobolome.

Conditions

  • Endometriosis
  • Probiotics

Interventions

DIETARY_SUPPLEMENT

Omni Biotic Stress

Multistrain probiotic formulation (Omni Biotic Stress), 1 sachet daily for 8 weeks

OTHER

Placebo

Inert powder identical in appearance and taste to probiotic, 1 sachet daily for 8 weeks

Sponsors & Collaborators

  • Clinical Hospital Centre Zagreb

    collaborator OTHER

  • The Gut Microbiome Center (Centar za crijevni mikrobiom)

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-11-01
Primary Completion
2025-05-01
Completion
2025-11-30

Countries

  • Croatia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06929364 on ClinicalTrials.gov