Interpersonal Communication Training and Vaccination Workflow Training Alone and in Combination to Improve Communication and Recommendations About HPV Vaccination in Pharmacies, IMPACT HPV Trial

Summary

This clinical trial compares usual care to interpersonal communication training and vaccination workflow training, alone or in combination, for improving communication about and recommendations for human papillomavirus (HPV) and other vaccinations in pharmacies. Low HPV vaccination in the United States has placed unvaccinated children at risk of developing cancers as adults that could have been prevented. Pharmacies can be convenient for vaccination because they are open longer hours, have shorter wait times, can see patients without appointments and may cost less. However, many people are not aware that vaccination is available in pharmacies and some pharmacies lack the commitment from staff to vaccinate or may not have protocols in place for vaccination. Proactive communication approaches to recommending HPV vaccination have been shown to be effective in medical offices but have not been tested in the pharmacy setting. Interpersonal communication training incorporates the 5 A's (assess, advice, agree, assist and arrange) behavioral counseling framework to strongly recommend HPV and other vaccines and effectively answer any questions or concerns about vaccination. Vaccination workflow training establishes vaccination decision support strategies that pharmacies use to improve vaccination workflows. Interpersonal communication training and vaccination workflow training alone or in combination may improve communication and recommendations for HPV vaccination and increase HPV vaccination in pharmacies.

Conditions

• Human Papillomavirus-Related Carcinoma

Interventions

OTHER

Best Practice

Provide vaccinations per usual care

OTHER

Educational Intervention

Review messages on safety and side effects

OTHER

Educational Intervention

Review messages on vaccine effectiveness

OTHER

Educational Intervention

Review messages on sexual activity

OTHER

Educational Intervention

Review messages on HPV vaccine for boys

OTHER

Educational Intervention

Review message on age to start vaccine

OTHER

Educational Intervention

Review messages on school entry requirements

OTHER

Interview

Ancillary studies

OTHER

Questionnaire Administration

Complete a survey

OTHER

Questionnaire Administration

Ancillary studies

BEHAVIORAL

Training and Education

Receive interpersonal communication training

BEHAVIORAL

Training and Education

Receive the vaccination workflow training

PROCEDURE

Vaccination

Provide vaccinations using the interpersonal communication strategy

PROCEDURE

Vaccination

Provide vaccinations using the vaccination workflow training strategy

PROCEDURE

Vaccination

Provide vaccinations using both the interpersonal communication strategy and the vaccination workflow training strategy

Sponsors & Collaborators

• Merck Sharp & Dohme LLC

  collaborator INDUSTRY

• Fred Hutchinson Cancer Center

  lead OTHER

Principal Investigators

• Parth Shah, PharmD, PhD · Fred Hutch/University of Washington Cancer Consortium

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-06-01

Primary Completion

2026-09-01

Completion

2027-10-01

Countries

• United States

Study Locations