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The Effect of Exercise on Metabolic Alteration

NCT06923163 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-01-21

No results posted yet for this study

Summary

The goal of this clinical trial is to study the effectiveness of aerobic exercise in treating obesity in adults and to assess the efficacy of exercise. The primary research questions it seeks to address are as follows:

* To what extent does exercise increase the total energy expenditure of participants?
* Why and how does the energy expenditure from exercise not fully compensate for the total energy expenditure (TEE)?
* Researchers will assess the efficacy and potential challenges of using exercise as a treatment for obesity by comparing the measurement data before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20).

Participants will engage in the following activities:

* Engage in running sessions supervised five times a week for a duration of 12 weeks.
* Attend laboratory sessions both before and after the exercise intervention period for metabolic and anthropometric measurements, as well as sample collection.
* Return to the laboratory for further metabolic and anthropometric measurements and sample collection8 weeks post-completion of exercise intervention.

Conditions

  • Sedentary Behavior
  • Healthy Participants
  • Adult

Interventions

BEHAVIORAL

Exercise intervention

Exercise prescription for participant， * 150Kcal for Weeks 1-4 (gradually increase to 150Kcal in the first two weeks as familiar stage), * 250Kcal for Weeks 5-8, * 350Kcal for Weeks 9-12.

Sponsors & Collaborators

  • Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

    lead OTHER

Principal Investigators

  • John R Speakman, PhD · Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-05-01
Primary Completion
2026-12-31
Completion
2027-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06923163 on ClinicalTrials.gov