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Orthobiologic Treatment for Knee Osteoarthritis

NCT06893250 · Status: ENROLLING_BY_INVITATION · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2025-03-25

No results posted yet for this study

Summary

The goal of this randomized clinical trial is to compare treatment for osteoarthritis in the knee using platelet rich plasma (PRP) or adipose stem cells (ADS). The main questions it aims to answer are:

* Will the patients clinically benefit from the treatment, and if so, which treatment is better?
* Will there be radiological findings to support this? Participants will be randomized into one of four groups: PRP, ADS, PRP + ADS or placebo treatment (saline) and will be examined and get an X-ray and MRI of the knee taken at inclusion and after 1 and 2 years.

Conditions

  • Osteoarthritis Knee

Interventions

BIOLOGICAL

PRP injection

Platelet rich plasma, blood from the patient that is centrifuged.

BIOLOGICAL

ADSTEM Inj. (Adult human mesenchymal stem cells)

Adipose tissue stem cells, from abdominal fat.

BIOLOGICAL

Injection

PRP + adipose tissue stem cells

BIOLOGICAL

Saline (NaCl 0,9 %) (placebo)

Sterile saline injection.

Sponsors & Collaborators

  • University Hospital of North Norway

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-09-23
Primary Completion
2025-12-31
Completion
2027-12-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06893250 on ClinicalTrials.gov