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Association Between Age-related Macular Degeneration and Cognitive Impairment Based on Exosome Proteomics

NCT06883461 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-03-19

No results posted yet for this study

Summary

Aim: Preliminary serum exosomal proteomics of patients with dry age-related macular degeneration (AMD) and mild cognitive impairment (MCI) were analyzed using proteomics technology.

Methods: Peripheral serum samples were collected from patients with AMD, MCI, comorbid conditions, and the control group. Exosomes were isolated from these samples and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Differentially expressed proteins (DEPs) associated with the two diseases were identified based on fold change and p-value. DEPs were analyzed by Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network analysis. Western blot and enzyme-linked immunosorbent assay (ELISA) were used to validate the DEPs of interest.

Conditions

  • Age Related Macular Degeneration
  • Mild Cognitive Impairment (MCI)
  • Alzheimer's Disease (AD)

Sponsors & Collaborators

  • Shanghai 10th People's Hospital

    lead OTHER

Eligibility

Min Age
40 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-01
Primary Completion
2024-06-03
Completion
2024-06-03

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06883461 on ClinicalTrials.gov