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Adaptation of Human Brown Adipose Tissue to Calorie Restriction

NCT06878989 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-05-12

No results posted yet for this study

Summary

The BATON study investigates how human brown adipose tissue (BAT) adapts to a controlled caloric restriction diet in young adults with obesity. A weight maintenance diet group will be compared to a group following a diet designed to induce an 8-10% weight loss over a 12-16 week period. Outcome assessments will include advanced technologies such as PET-CT and molecular analyses of BAT. The overarching goal is to gain a deeper understanding of the role of human BAT on the regulation of body weight.

Conditions

  • Obesity and Overweight

Interventions

BEHAVIORAL

Caloric restriction diet

Dietary intervention consisting on a meal plan designed to induce an 8-10% weight loss over a 12-16 week period.

BEHAVIORAL

Weight maintenance diet

Dietary intervention consisting on a meal plan designed to maintain a stable body weight for up to 16 weeks.

Sponsors & Collaborators

  • Hospital Clinico Universitario San Cecilio

    collaborator OTHER

  • University Hospital Virgen de las Nieves

    collaborator OTHER

  • Universidad de Granada

    lead OTHER

Principal Investigators

  • Guillermo Sanchez Delgado, Ramon y Cajal Researcher · Universidad de Granada

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-25
Primary Completion
2026-08-31
Completion
2026-12-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06878989 on ClinicalTrials.gov