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Rapid Diagnostic Technology for AUGIB Based on Analysis of VOCs in Exhaled Breath

NCT06877507 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2025-03-14

No results posted yet for this study

Summary

This study aims to develop a non-invasive and rapid diagnostic technology for acute upper gastrointestinal bleeding (AUGIB) by analyzing volatile organic compounds (VOCs) in exhaled breath. Clinically confirmed patients will be divided into three groups (no bleeding, minor bleeding, major bleeding) based on endoscopic findings. VOC profiles will be analyzed to construct a predictive model, validated for sensitivity and specificity (both targets ≥0.7). This approach addresses the limitations of endoscopy in emergency or resource-limited settings, improving diagnostic efficiency and reducing mortality.

Conditions

  • Volatile Organic Compound
  • Gastrointestinal Hemorrhage

Interventions

DEVICE

Gastroscopy

Gastroscopy for all included patients

DIAGNOSTIC_TEST

Gas Chromatography - Mass Spectrometry

Using a patient's exhaled breath test with Gas Chromatography - Mass Spectrometry

Sponsors & Collaborators

  • Beijing 302 Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-20
Primary Completion
2025-07-20
Completion
2025-07-20

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06877507 on ClinicalTrials.gov