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Neuroinflammation in FTLD

NCT06870838 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2025-09-11

No results posted yet for this study

Summary

The goal of this observational study is to investigate the role of neuroinflammation in frontotemporal lobar degeneration (FTLD). The main aims of this study are:

1. To elucidate the role and timing of neuroinflammation in FTLD by using a combination of clinical measures, 7T MRI, and CSF biomarkers;
2. To differentiate FTLD-TDP and FTLD-tau during life using biomarkers for neuroinflammation;
3. To identify biomarkers to predict and monitor disease progression in FTLD;

Secondary aim:

1\. To explore the role of brain clearance in the disease process of FTLD.

Participants will undergo 7T MRI scans, blood and CSF collection, clinical, neurological, and neuropsychological evaluation.

Conditions

  • Corticobasal Syndrome(CBS)
  • Primary Progressive Aphasia(PPA)
  • Progressive Supranuclear Palsy(PSP)
  • Behavioral Variant Frontotemporal Dementia (bvFTD)
  • Frontotemporal Lobar Degeneration (FTLD)

Interventions

DIAGNOSTIC_TEST

7T MRI scan

MRI-scanning of the brain using a 7T MRI scanner

DIAGNOSTIC_TEST

CSF

CSF collection via lumbar puncture

DIAGNOSTIC_TEST

Blood withdrawal

Blood is collected by doing a blood withdrawal

DIAGNOSTIC_TEST

Neuropsychological assessment

Tests for memory, language, attention, executive functions, praxis, social cognition, visuoconstructive skills

DIAGNOSTIC_TEST

Clinical measures

Medical history, neurological assessment, neuropsychiatric inventory

Sponsors & Collaborators

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-25
Primary Completion
2025-08-01
Completion
2026-08-31

Countries

  • Netherlands

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06870838 on ClinicalTrials.gov