Consolidation Therapy With Cladribine in Relapsing Multiple Sclerosis Patients
NCT06854094 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 70
Last updated 2026-03-12
Summary
To investigate the impact on IgG and IgM concentration, infection risk and effectiveness of switching from anti-CD20 to cladribine compared to continued anti-CD20 treatment over 2 years in relapsing MS patients.
Conditions
Sponsors & Collaborators
-
3B Biotech Research
collaborator OTHER -
Ente Ospedaliero Cantonale, Bellinzona
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-10-03
- Primary Completion
- 2026-12-31
- Completion
- 2028-12-31
Countries
- Switzerland
Study Locations
More Related Trials
-
The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis
NCT00917839 ·Status: UNKNOWN ·Phase: PHASE2
-
Cladribine Tablets: Collaborative Study to Evaluate Impact On Central Nervous System Biomarkers in Multiple Sclerosis
NCT03963375 ·Status: COMPLETED ·Phase: PHASE4
-
Exploratory Study of the Safety, Tolerability and Efficacy of Multiple Regimens of Natalizumab in Adult Participants With Relapsing Multiple Sclerosis (MS)
NCT01405820 ·Status: COMPLETED ·Phase: PHASE2
-
A Safety and Efficacy Study of Oral Cladribine in Subjects With Relapsing-remitting Multiple Sclerosis (RRMS)
NCT00213135 ·Status: COMPLETED ·Phase: PHASE3
-
Rehabilitative Protocols in Progressive Multiple Sclerosis Treated with Anti CD20 Monoclonal Antibodies
NCT06894940 ·Status: COMPLETED ·Phase: PHASE2
-
Double Blind Combination of Rituximab by Intravenous and Intrathecal Injection Versus Placebo in Patients With Low-Inflammatory Secondary Progressive Multiple Sclerosis (RIVITaLISe)
NCT01212094 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Phase 2 Study of Cladribine Add-on to Interferon-beta (IFN-beta) Therapy in Multiple Sclerosis (MS) Subjects With Active Disease (ONWARD)
NCT00436826 ·Status: COMPLETED ·Phase: PHASE2
-
A Prospective Randomized Non-inferiority Trial Comparing Anti-CD20 Maintenance Versus De-Escalation Strategy In Relapsing-Remitting Multiple Sclerosis
NCT07189325 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Three Months Treatment With SB683699 In Patients With Relapsing Multiple Sclerosis
NCT00097331 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluate Early Glatiramer Acetate Treatment in Delaying Conversion to Clinically Definite Multiple Sclerosis of Subjects Presenting With Clinically Isolated Syndrome
NCT00666224 ·Status: COMPLETED ·Phase: PHASE3
-
Study of the Safety and Efficacy of MLN1202 in Patients in Multiple Sclerosis
NCT01199640 ·Status: COMPLETED ·Phase: PHASE2
-
Safety of RG2077 in Patients With Multiple Sclerosis
NCT00076934 ·Status: COMPLETED ·Phase: PHASE1
-
Natalizumab De-escalation to Interferon-beta-1b in Patients With Relapsing-remitting Multiple Sclerosis
NCT01701856 ·Status: TERMINATED ·Phase: PHASE4
-
Study of Teriflunomide in Reducing the Frequency of Relapses and Accumulation of Disability in Patients With Multiple Sclerosis
NCT00134563 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
NCT06735248 ·Status: RECRUITING ·Phase: PHASE2
-
Study of Subcutaneous Daclizumab in Patients With Active, Relapsing Forms of Multiple Sclerosis
NCT00109161 ·Status: COMPLETED ·Phase: PHASE2
-
Multiple Doses of Anti-NOGO A in Relapsing Forms of Multiple Sclerosis
NCT01435993 ·Status: TERMINATED ·Phase: PHASE1
-
Comparison of Rituximab Induction Therapy Followed by Glatiramer Acetate
NCT01569451 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Suboptimally Controlled Participants Previously Taking Oral or Infusion DMDs for RMS (MASTER-2)
NCT03933202 ·Status: COMPLETED
-
Cladribine Tablets as an Exit Therapy Strategy
NCT06887426 ·Status: NOT_YET_RECRUITING
-
Prospective Effectiveness and Safety Study of Cladribine in Participants Who Change First-line DMD Treatments for Multiple Sclerosis (CLAD CROSS)
NCT04934800 ·Status: COMPLETED
-
Safety and Efficacy of Intrathecal Rituximab in Patients With Multiple Sclerosis
NCT05078177 ·Status: UNKNOWN ·Phase: PHASE1
-
An Intravenous Infusion Study of rHIgM22 in Patients With Multiple Sclerosis Immediately Following a Relapse
NCT02398461 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Cladribine Treatment on Microglial Activation in the CNS
NCT04239820 ·Status: ACTIVE_NOT_RECRUITING
-
Predicting Disease Activity and Rebound Risk in MS Patients Treated With Sphingosine-1-phosphate Receptor Modulators (S1PRM)
NCT05828901 ·Status: TERMINATED