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SMS - Study of Somatic Mutations Using Genome Sequencing

NCT06851052 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2025-07-20

No results posted yet for this study

Summary

Disease and tissue aging are thought to be influenced by genetic changes, or mutations, acquired throughout life. These mutations provide clues regarding the genetic damage that occurred through the lifetime of the patient, and include mutations caused by environmental factors such as ultraviolet light from sunlight or tobacco smoke affecting the skin or internal tissues, respectively. Other mutations may occur due to errors in copying the genome as cells divide. Improvements in technologies that read the genetic code have made it possible for all or selected parts of the genetic code of a human being to be "sequenced", allowing mutations (changes in the genetic code) to be detected.

Conditions

  • Somatic Mutation

Interventions

OTHER

sample collection

Samples could include blood, skin biopsy, urine, plucked hair.

OTHER

Seeking consent

OTHER

Sample Collection: Surgical

Excess surgical tissue (diseased tissue or tissue being removed for a clinical reason).

Sponsors & Collaborators

  • Cambridge University Hospitals NHS Foundation Trust

    collaborator OTHER

  • Hull University Teaching Hospitals NHS Trust

    collaborator OTHER_GOV

  • The Wellcome Sanger Institute

    lead OTHER

Principal Investigators

  • Phil Jones, PhD · Wellcome Sanger Institute

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-10-01
Primary Completion
2028-06-14
Completion
2028-07-14

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06851052 on ClinicalTrials.gov