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Bite Force Measurements

NCT06843525 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 112

Last updated 2025-07-24

No results posted yet for this study

Summary

ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids. Addressing the need for non-opioid pain alternatives is crucial. Emerging evidence suggests that dental pain from pulpal and periodontal conditions (affecting the tooth's nerve and surrounding tissues) involves neuropathic mechanisms, such as mechanical allodynia (MA) and central sensitization (CS). These mechanisms can amplify pain perception, causing typically non-painful actions, like chewing, to become painful and resulting in hypersensitivity extending beyond the affected tooth. Reliably identifying these mechanisms with quantitative measures can support improved pain assessment and targeted non-opioid treatment. This minimally invasive prospective cohort study will use the FDA-approved Innobyte® device, a precise bite-force measurement tool, to evaluate periodontal health and to quantify mechanical pain thresholds in patients requiring endodontic treatment (root canal therapy).

Conditions

  • Irreversible Pulpitis
  • Apical Periodontitis
  • Pulpal Necrosis

Sponsors & Collaborators

  • New Jersey Alliance for Clinical and Translational Science

    collaborator UNKNOWN

  • Rutgers, The State University of New Jersey

    lead OTHER

Principal Investigators

  • Varvara Vanessa Chrepa, DDS, MS, PhD · Rutgers School of Dental Medicine

  • Gayathri Subramanian, PhD, DMD · Rutgers School of Dental Medicine

Eligibility

Min Age
18 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-16
Primary Completion
2026-04-01
Completion
2026-11-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06843525 on ClinicalTrials.gov