A Study to Investigate the Sequencing Strategy of Pirtobrutinib After Disease Progression on First-line Acalabrutinib Treatment for Adult Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT06839872 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL
Last updated 2025-06-05
Summary
To assess the efficacy and safety of pirtobrutinib in participants with CLL/SLL who have progressed on first-line treatment with acalabrutinib.
Conditions
Interventions
- DRUG
-
Pirtobrutinib
Patients will receive pirtobrutinib orally with dosing schedule as prescribed
- DRUG
-
Patients will receive acalabrutinib orally with dosing schedule as prescribed.
Sponsors & Collaborators
- collaborator INDUSTRY
- lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 110 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-06-30
- Primary Completion
- 2028-07-28
- Completion
- 2030-07-29
- FDA Drug
- Yes
More Related Trials
-
Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT04666038 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Early Intervention With Acalabrutinib in Patients With High Risk CLL
NCT04660045 ·Status: WITHDRAWN ·Phase: PHASE2
-
Acalabrutinib in Patients With Relapsed/Refractory and Treatment naïve Deletion 17p CLL/SLL
NCT02337829 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT05254743 ·Status: RECRUITING ·Phase: PHASE3
-
Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT03516617 ·Status: RECRUITING ·Phase: PHASE2
-
Observational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United Kingdom
NCT05557695 ·Status: RECRUITING
-
ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia
NCT02029443 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi
NCT06466122 ·Status: RECRUITING ·Phase: PHASE2
-
A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT06973187 ·Status: RECRUITING ·Phase: PHASE3
-
Pirtobrutinib (LOXO-305) Consolidation for MRD Eradication in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL) Treated With Venetoclax
NCT05317936 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Acalabrutinib for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT06757647 ·Status: RECRUITING ·Phase: PHASE2
-
Predictors of Health-Related QOL in Adults With CLL or Small Lymphocytic Lymphoma
NCT07030400 ·Status: RECRUITING
-
Phase 1/2 Study of TP-0903 (an Inhibitor of AXL Kinase) in Patients With Previously Treated CLL
NCT03572634 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
NCT05057494 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Multicenter Study of Pacritinib Combined With Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
NCT02677948 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
NCT06651970 ·Status: RECRUITING ·Phase: PHASE4
-
Chemotherapy in Treating Patients With Chronic Lymphocytic Leukemia
NCT00006097 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Cilengitide in Treating Patients With Acute Myeloid Leukemia
NCT00089388 ·Status: TERMINATED ·Phase: PHASE2
-
Acalabrutinib in Combination With ACP-319, for Treatment of Chronic Lymphocytic Leukemia
NCT02157324 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLL
NCT07342478 ·Status: RECRUITING ·Phase: PHASE3
-
Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL
NCT01722487 ·Status: COMPLETED ·Phase: PHASE3
-
A Time-Limited Approach to Treatment With Ibrutinib for Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
NCT04694560 ·Status: WITHDRAWN
-
Acalabrutinib Safety Study in Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia Patients
NCT04008706 ·Status: COMPLETED ·Phase: PHASE3
-
A Practical Clinical Study Comparing the Fixed-cycle Regimen Containing Orelabrutinib With BTKi Monotherapy
NCT06476899 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Eltrombopag in Thrombocytopenic Chronic Lymphocytic Leukemia (CLL) Patients (CLL2S Study of GCLLSG)
NCT01397149 ·Status: TERMINATED ·Phase: PHASE1/PHASE2