A Prospective, Multicenter, Observational Cohort Study to Evaluate the Efficacy and Safety of a Novel Anti-tumor Drug As a Radiosensitizer in Patients with Advanced Breast Cancer Brain Metastasis.
NCT06839547 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100
Last updated 2025-02-21
Summary
A prospective, multicenter, observational cohort study to evaluate the efficacy and safety of a novel anti-tumor drug as a radiosensitizer in patients with advanced breast cancer brain metastasis.
Conditions
- Advanced Breast Cancer Brain Metastasis
Interventions
- DRUG
-
Radiotherapy + Novel Anti-tumor Drug
1. Novel anti-tumor drugs \[including: ADC drugs (such as T-DXd, T-DM1, etc.), CDK4/6 inhibitors, TKI drugs (such as Pyrotinib, Tucatinib, etc.), novel chemotherapy drugs (such as Utidelone, Irinotecan liposomes, etc.), Bevacizumab, PD-1/PD-L1 inhibitors, etc.\] 2. Radiotherapy
Sponsors & Collaborators
-
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-03-01
- Primary Completion
- 2028-09-10
- Completion
- 2028-09-10
More Related Trials
-
Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases
NCT04711824 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Simvastatin Effect on Radiation Therapy of Brain Metastases
NCT02104193 ·Status: COMPLETED ·Phase: PHASE2
-
Adebrelimab Plus Apatinib and Etoposide for the Treatment of HER2-Negative Breast Cancer Brain Metastasis
NCT06418594 ·Status: RECRUITING ·Phase: PHASE2
-
A Single Arm Study of Brain Metastasis in Patients With HER2-positive Breast Cancer
NCT04767828 ·Status: UNKNOWN ·Phase: PHASE4
-
Pyrotinib, Trastuzumab And Abraxane in HER2-positive MBC With Brain Metastasis
NCT04639271 ·Status: UNKNOWN ·Phase: PHASE2
-
A Multi-Center Study of Lapatinib in Patients With Trastuzumab-refractory Metastatic Breast Cancer
NCT02362958 ·Status: COMPLETED ·Phase: PHASE2
-
Trastuzumab Rezetecan Combined With Radiotherapy Versus Trastuzumab Rezetecan in the Treatment of HER2-positive Advanced Breast Cancer With Brain Metastases
NCT07100600 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of Pyrotinib Plus Capecitabine in Patients With Brain Metastases From HER2-positive Metastatic Breast Cancer
NCT03691051 ·Status: UNKNOWN ·Phase: PHASE2
-
Radiotherapy with Immunotherapy and Anti-Angiogenic Therapy for Advanced HER2-Negative Breast Cancer: a Single-Arm Study
NCT06890871 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE1/PHASE2
-
Metronomic Chemotherapy in a Real-world Population of Advanced Breast Cancer Patients
NCT06373744 ·Status: COMPLETED
-
Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis
NCT01281696 ·Status: COMPLETED ·Phase: PHASE2
-
Safety Assessment of Concurrent Radiotherapy and Novel Systemic Therapy for Breast Cancer
NCT06197581 ·Status: RECRUITING ·Phase: NA
-
Pyrotinib Combined With Capecitabine in HER-2 Positive Advanced Breast Cancer and Brain Metastases (Post-PERMEATE)
NCT05359120 ·Status: UNKNOWN
-
Brain Irradiation and Tremelimumab in Metastatic Breast Cancer
NCT02563925 ·Status: COMPLETED ·Phase: NA
-
Evaluation of Trop-2 ADC in Breast Cancer Patients With Brain Metastases: A Real-World Study
NCT07251868 ·Status: RECRUITING
-
Study of Etoposide in Treating Patients With Recurrent or Metastatic Breast Cancer
NCT01492556 ·Status: UNKNOWN ·Phase: PHASE2
-
Lapatinib in Combination With Radiation Therapy in Patients With Brain Metastases From HER2-Positive Breast Cancer
NCT00470847 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase Ⅱ Study of an All-Oral Combination of Low-dose Etoposide/Capecitabine in Patients With Metastatic Breast Cancer Previously Treated With Anthracyclines and/or Taxanes
NCT01589159 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Study of Apatinib Combined With SBRT Therapy in the Treatment of Oligometastasis of Breast Cancer
NCT03457467 ·Status: UNKNOWN ·Phase: PHASE2
-
Investigating the Effectiveness of Stereotactic Body Radiotherapy (SBRT) in Addition to Standard of Care Treatment for Cancer That Has Spread Beyond the Original Site of Disease
NCT03808337 ·Status: RECRUITING ·Phase: PHASE2
-
Oral Metronomic Capecitabine Combined With Pyrotinib in ADC-treated HER2-positive Metastatic Breast Cancer
NCT07019337 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Herceptin (Trastuzumab) in Combination With Whole Brain Radiotherapy in Patients With HER-2 Positive Breast Cancer
NCT01363986 ·Status: TERMINATED ·Phase: PHASE2
-
An All-Oral Combination of Capecitabine and Cyclophosphamide in Patients With Metastatic Breast Cancer (MBC)
NCT00589901 ·Status: UNKNOWN ·Phase: PHASE2
-
UTD1 Combined With Capecitabine in Metastatic HER2-negative Breast Cancer Patients With Brain Metastases
NCT05535413 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
SHR-A1811 and THPy in First or Second Line for HER2 Positive Advanced Breast Cancer Brain Metastases
NCT06975475 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2