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TMS-related Measures as Biomarker of Cognitive Impairment in PD

NCT06835595 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2025-12-22

No results posted yet for this study

Summary

The goal of the present study is to explore the diagnostic and prognostic value of neurophysiological biomarkers obtained through paired-pulse Transcranial Magnetic Stimulation (TMS) techniques in individuals affected by Parkinson's disease (PD) with and without cognitive decline.

The main questions it aims to answer are:

* TMS measures of cortical excitability are able to distinguish between PD patients cognitively normal, PD-Mild Cognitive Impairment (PD-MCI) and PD-Dementia (PD-D)?
* TMS measures of cortical excitability are able to predict progression of PD patient cognitive status from cognitively normal to PD-MCI and PD-D?

Conditions

  • Parkinson Disease

Interventions

DIAGNOSTIC_TEST

Transcranial Magnetic Stimulation

Paired stimulation protocols of TMS to collect SAI, SICI, ICF measures

Sponsors & Collaborators

  • Azienda Provinciale per i Servizi Sanitari, Provincia Autonoma di Trento

    lead OTHER

Principal Investigators

  • Luigi Cattaneo, MD, PhD · CIMEC - Centro Interdipartimentale Mente Cervello - Università degli studi di Trento

  • Ruggero Bacchin, MD · UOC Neurologia - Azienda Sanitaria per i Servizi Sanitari (APSS)

  • Bruno Giometto, MD · CISMED - Centro Interdipartimentale di Scienze Mediche - Università degli studi di Trento

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-10
Primary Completion
2029-01-01
Completion
2029-01-01

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06835595 on ClinicalTrials.gov