A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease
NCT06830629 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 56
Last updated 2026-04-17
Summary
This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease
Conditions
- Proteinuric Kidney Disease
Interventions
- DRUG
-
MZE829
Capsules for oral administration
Sponsors & Collaborators
-
Maze Therapeutics
lead INDUSTRY
Principal Investigators
-
Medical Director · Maze Therapeutics
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 68 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-02-05
- Primary Completion
- 2026-09-30
- Completion
- 2026-09-30
- FDA Drug
- Yes
Countries
- United States
- France
- United Kingdom
Study Locations
More Related Trials
-
A Phase I Clinical Study of Recombinant Humanized Anti-CD20(B-lymphocyte Antigen CD20) Monoclonal Antibody Subcutaneous Injection in the Treatment of Primary Membranous Nephropathy
NCT05668403 ·Status: RECRUITING ·Phase: PHASE1
-
A Study to Learn About How Well BAY3283142 Works and Its Safety in Participants With Chronic Kidney Disease
NCT06522997 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease
NCT06500702 ·Status: RECRUITING ·Phase: PHASE2
-
A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006)
NCT07348237 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of RGLS8429 in Patients With Autosomal Dominant Polycystic Kidney Disease
NCT05521191 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of PRT-201 Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-1)
NCT02110901 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Understand the Genetics and Clinical Course of Focal Segmental Glomerulosclerosis (FSGS), Treatment-Resistant Minimal Change Disease (TR-MCD), and Diabetic Nephropathy (DN)
NCT04235621 ·Status: TERMINATED
-
Safety and Efficacy Study of AB023 (Xisomab 3G3) in End Stage Renal Disease Patients on Chronic Hemodialysis
NCT03612856 ·Status: COMPLETED ·Phase: PHASE2
-
Phase 2a Study to Evaluate PRS-080 in Anemic Chronic Kidney Disease Patients
NCT03325621 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Phase 1 Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ManNAc in Subjects With Primary Podocyte Diseases
NCT02639260 ·Status: COMPLETED ·Phase: PHASE1
-
A Clinical Trial With KJ103 in Anti-GBM Disease
NCT06607016 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Crossover Pilot Study of the Effect of Amiloride on Proteinuria
NCT02522650 ·Status: UNKNOWN ·Phase: PHASE4
-
A Study of Mezagitamab in Adults With Primary Immunoglobulin A Nephropathy Receiving Stable Background Therapy
NCT05174221 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Participants With End-Stage Renal Disease
NCT01200290 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Safety and Efficacy of AZD5718 in Participants With Proteinuric Chronic Kidney Disease
NCT04492722 ·Status: TERMINATED ·Phase: PHASE2
-
The Efficacy of Prednisone and Combination Therapy With Methylprednisolone and Cyclophosphamide on IMN in Stage I.
NCT03466801 ·Status: TERMINATED ·Phase: NA
-
An Open-Label, Long-term Study of GFB-887 in Patients With Glomerular Kidney Diseases
NCT04950114 ·Status: TERMINATED ·Phase: PHASE2
-
Safety and Efficacy of ANX-042 in Human Cardiorenal Syndrome
NCT03019653 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Pharmacokinetics Study of MBX 2109 in Adult Subjects With Normal and Impaired Renal Function
NCT06496217 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Learn More About the Effects and Safety of JMT601 in Adults With Primary Membranous Nephropathy
NCT07029139 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
The MC2-25 Cream in Subjects wITh CHronic KIdNEy Disease-aSsociated prurituS (ITCHINESS) Trial
NCT05482698 ·Status: COMPLETED ·Phase: PHASE2
-
Pilot Study of ACTH in the Treatment of Immunoglobulin A (IgA) Nephropathy at High Risk of Progression
NCT02282930 ·Status: COMPLETED ·Phase: PHASE3
-
A Clinical Study of B007 in the Treatment of Primary Membranous Nephropathy.
NCT06470191 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
A Phase 2a Study of Weekly Doses of GCS-100 in Patients With Chronic Kidney Disease
NCT01843790 ·Status: COMPLETED ·Phase: PHASE2
-
Trial of Plasma Exchange for Acute Renal Failure at the Onset of Myeloma
NCT00120263 ·Status: COMPLETED ·Phase: NA