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Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants

NCT06829368 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2026-05-22

No results posted yet for this study

Summary

This study examines the impact of theta-burst transcranial focused ultrasound stimulation (tFUS) on cognitive performance in healthy participants, specifically focusing on both acute and post-stimulation effects on visual working memory (vWM). The investigation will compare TUS effects across targeted deep cortical and subcortical brain regions involved in cognitive processing. Neurophysiological changes following stimulation will be assessed using EEG, providing insight into tFUS-induced modulations in working memory-related brain activity.

Conditions

  • Cognitive Enhancement

Interventions

OTHER

Transcranial Focused Ultrasound Stimulation

Using MRI neuronavigation, the investigators will implement theta-burst tFUS in one of the four targets.

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Marcus Kaiser, Professor of Neuroinformatics · University of Nottingham

  • Mohammad Katshu, Clinical Associate Professor · University of Nottingham

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-20
Primary Completion
2026-03-14
Completion
2026-03-14

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06829368 on ClinicalTrials.gov