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Orthodontic Treatment on Oral Microbiota and Salivary Proteins

NCT06824493 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2025-06-04

No results posted yet for this study

Summary

Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.

Conditions

  • Orthodontics
  • White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
  • Caries, Dental

Interventions

OTHER

no interventions

no intervention as this is an observational studies

OTHER

None-placebo

Observational study with no interventions

OTHER

No Intervention: Observational Cohort

no intervention because of observational studies

Sponsors & Collaborators

  • Xi'an Jiaotong University

    lead OTHER

Eligibility

Min Age
6 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2027-03-01
Completion
2027-09-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06824493 on ClinicalTrials.gov