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The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow

NCT06823843 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-03-28

No results posted yet for this study

Summary

The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography. The main questions it aims to answer are:

* Does sublingual nitroglycerin change absolute coronary blood flow compared to placebo?
* What is the effect of sublingual nitroglycerin on important cardioavascular parameters such as coronary pressure and resistance?

Researchers will compare the sublingual nitroglycerin group to the placebo group to see if nitroglycerin leads to significant changes in coronary blood flow and microvascular function.

Participants will:

* Receive either sublingual nitroglycerin or a placebo during coronary angiography.
* Undergo coronary blood flow measurements before and after the intervention using standardized assessment techniques.

Conditions

  • Coronary Arterial Disease (CAD)
  • Angina (Stable)

Interventions

DRUG

Glycerin trinitrate (GTN)

2 sublingual puffs for a total dose of 800 µg

DRUG

Saline (NaCl 0,9 %) (placebo)

2 puffs of sublingual saline

Sponsors & Collaborators

  • VZW Cardiovascular Research Center Aalst

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2024-09-30
Completion
2024-09-30

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06823843 on ClinicalTrials.gov