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Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome

NCT06821568 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 128

Last updated 2025-09-22

No results posted yet for this study

Summary

The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function, dual task standing and walking, and other metrics of mobility in older adults with motoric cognitive risk syndrome (MCR).

Conditions

  • Alzheimer Disease and Related Dementias
  • Cognition
  • Mobility Disability

Interventions

OTHER

Personalized Transcranial Direct Current Stimulation (tDCS)

Home-based transcranial direct current stimulation (tDCS) tailored to target the left dlPFC.

OTHER

Active-Sham

Stimulation administered in very low-level currents (0.5 mA total) designed to not significantly influence cortical tissue, but still mimic the cutaneous sensations induced by tDCS.

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • Tel Aviv Medical Center

    collaborator OTHER

  • Hebrew SeniorLife

    lead OTHER

Principal Investigators

  • Brad Manor, PhD · Hebrew SeniorLife

  • Jeff Hausdorff, PhD · Tel-Aviv Sourasky Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
65 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-02
Primary Completion
2029-03-31
Completion
2029-06-30

Countries

  • United States
  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06821568 on ClinicalTrials.gov