Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery
NCT06810375 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 120
Last updated 2026-04-09
Summary
This clinical trial compares efficacy in postoperative pain management in thoracic surgery between erector spinae block versus liposomal bupivacaine injections.
Conditions
Interventions
- DRUG
-
Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)
preoperative erector spinae block with bupivacaine (Marcaine®)
- DRUG
-
Intercostal nerve block
intraoperative intercostal nerve block with liposomal bupivacaine (Exparel®)
Sponsors & Collaborators
-
George Washington University
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 90 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-03-01
- Primary Completion
- 2028-02-28
- Completion
- 2029-02-28
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Block and Erector Comparative Study Between Costotransverse Spinae Plane Block in Patients Undergoing Thoracotomy
NCT06301334 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Erector Spinae Plane Block For Analgesia Following Video-Assisted Thoracoscopic Surgery
NCT03860480 ·Status: COMPLETED ·Phase: NA
-
A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery
NCT06529432 ·Status: RECRUITING ·Phase: PHASE2
-
Randomized Trial of Erector Spinae Plane Block Using Liposomal Bupivacaine Versus Bupivacaine Hydrochloride on Quality of Recovery for Video-assisted Thoracic Surgery
NCT07141667 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Pain After Lung Cancer Surgery - Comparing Traditional Versus Prolonged Release Nerve Blockades
NCT05038007 ·Status: UNKNOWN ·Phase: PHASE2
-
Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial
NCT03508830 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Exparel Versus Epidural for Pain Control After Thoracotomy
NCT02178553 ·Status: COMPLETED ·Phase: PHASE4
-
Postoperative Pain Control With Lipossomic Extended Release Bupivacaine
NCT03560362 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies
NCT06252662 ·Status: RECRUITING ·Phase: PHASE4
-
Utility of Exparel Based ESP Blocks in Elective Posterior Spine Fusion
NCT06107660 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Effect of Erector Spinae (ESP) Block on Opioid Reduction and Enhanced Recovery After Posterior Cervical Spine Surgery
NCT04646707 ·Status: RECRUITING ·Phase: NA
-
Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1
NCT07254650 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Erector Spinae Plane Block for Video-assisted Thoracoscopic Surgery
NCT03628040 ·Status: UNKNOWN ·Phase: PHASE3
-
Liposomal Bupivacaine for Pain Control Following Thoracic Surgery.
NCT03036085 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Dispersion Following ESP Versus ITP Blocks Using Lidocaine Study
NCT06843343 ·Status: COMPLETED ·Phase: PHASE4
-
ER-One: A Double-blind Trial of Erector Spinae Block (ESP) Versus Paravertebral Block (PVB) Before Breast Cancer Surgery
NCT04827030 ·Status: COMPLETED ·Phase: PHASE4
-
Exparel and Marcaine for Pain Management in Thoracoscopic Lobectomy Patients
NCT03682224 ·Status: COMPLETED ·Phase: PHASE3
-
Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures
NCT03859635 ·Status: COMPLETED ·Phase: PHASE3
-
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management: A Pilot Study
NCT03936387 ·Status: COMPLETED ·Phase: PHASE3
-
Comparing Quality of Recovery Between ESPB and IV Lidocaine After Major Breast Cancer Surgery
NCT06490718 ·Status: COMPLETED ·Phase: NA
-
Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy
NCT01802411 ·Status: COMPLETED ·Phase: PHASE3
-
Pectoralis (II) Block With Liposomal Bupivacaine vs Bupivacaine for Breast Surgery
NCT03383198 ·Status: TERMINATED ·Phase: PHASE4
-
Erector Spinae Block for Spine Surgery
NCT05417113 ·Status: TERMINATED ·Phase: PHASE4
-
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management
NCT04567407 ·Status: COMPLETED ·Phase: PHASE4
-
Erector Spinae Regional Anesthesia for Pain Control
NCT05794828 ·Status: COMPLETED ·Phase: EARLY_PHASE1