MedTrace Logo

Synovial Proliferation on Routine Ultrasound: Active or Inactive?

NCT06809972 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 46

Last updated 2026-05-05

No results posted yet for this study

Summary

There is cumulating evidence for the presence of non-observed or subclinical joint bleeding in patients with haemophilia. Early detection of active subclinical synovial proliferation would allow early intervention in order to prevent deterioration of joint health. Patients with subclinical (=non-observed) signs of synovial proliferation in knee(s), ankle(s) and/or elbow(s) will be invited to participate in this study to further characterize the synovial proliferation status (active or inactive) by means of physical examination, MRI, ultrasound and elastography. Synovial proliferation status will be monitored for a maximum period of 12 weeks, during which participants will also receive standard-of-care treatment, i.e. administration of optimized coagulation factor replacement therapy and prescription of the NSAID celecoxib (optional).

Conditions

Interventions

OTHER

Ultrasound imaging

Ultrasound, MRI and elastography to screen for and follow subclinical synovial changes in ankle, elbow and knee.

Sponsors & Collaborators

  • Van Creveldkliniek

    lead OTHER

Principal Investigators

  • Lize van Vulpen, MD, PhD · University Medical Center Utrecht - Van Creveldkliniek

Eligibility

Min Age
12 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2028-01-01
Completion
2028-04-01

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06809972 on ClinicalTrials.gov