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Topical Tartrazine for Improved Skin Structure Visualization in Dermatology

NCT06800183 · Status: WITHDRAWN · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL

Last updated 2025-11-14

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if the topical application of tartrazine, an FDA-approved food dye, can help improve the transparency of the skin in healthy volunteers. The main questions it aims to answer are:

* Can topical tartrazine application allow for temporary skin transparency?
* What dose of tartrazine is required to achieve reversible skin transparency?

Participants will:

* Be given a patch test with four different doses of tartrazine
* Have these patch tests placed on the back, stomach, and forearm
* Have photographs taken every 5 minutes to see if transparency is achieved
* Be called 48 hours later to check for any side effects

Conditions

  • Healthy
  • Dermoscopy
  • Optical Imaging

Interventions

DRUG

Four-Chamber Tartrazine Patch across 3 Body Sites

This is a chamber patch comprising four increasing doses of tartrazine (0.15M, 0.3M, 0.6M, 1.2M). This will be applied on the forearm, abdomen, and back to represent different skin thicknesses.

Sponsors & Collaborators

Principal Investigators

  • Joel Sunshine, MD, PhD · Johns Hopkins University

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-11
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06800183 on ClinicalTrials.gov