Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors

Summary

This clinical trial evaluates the impact of a research intervention of virtually supervised exercise program (RISE) on cancer-related cognitive impairment (CRCI), physical activity in adolescent and young adult (AYA) brain tumor survivors. This clinical trial also evaluates the impact of RISE on the collection of microorganisms that exist in the intestines (gut microbiome). Up to 45% of AYA brain tumor survivors experience CRCI, including issues with attention and memory. CRCI can have a negative impact on education, independent living and can worsen long-term quality of life. Moderate-intensity levels of exercise, particularly aerobic and resistance training, have been shown to improve cognitive function. Additionally, exercise can change the composition and function of the gut microbiome, which may lead to improved cognitive function. Unfortunately, only about 50% of AYAs with cancer receive exercise information or meet the physical activity recommendations. Tailoring a virtually delivered exercise intervention to meet the unique needs of AYAs may improve access to exercise. Participating in the virtual home-based exercise intervention, RISE, may improve physical activity and cognitive impairment in AYA brain tumor survivors and may also help researchers understand the relationship of exercise on the gut microbiome and cognitive function.

Conditions

• Cancer-related Cognitive Dysfunction
• Primary Brain Neoplasm

Interventions

OTHER

Aerobic Exercise

Participate in personalized, progressive aerobic training

BEHAVIORAL

Behavioral Intervention

Receive active lifestyle behavior coaching

PROCEDURE

Follow-Up

Receive calls from the trainer

OTHER

Internet-Based Intervention

Receive access to Physitrack

OTHER

Medical Device Usage and Evaluation

Wear a Fitbit monitor

OTHER

Questionnaire Administration

Ancillary studies

OTHER

Resistance Training

Participating in strength training exercises

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• NRG Oncology

  collaborator OTHER

• Emory University

  lead OTHER

Principal Investigators

• Jinbing Bai, PhD, RN · Emory University

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

15 Years

Max Age

39 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-02-13

Primary Completion

2026-07-31

Completion

2027-07-31

Countries

• United States

Study Locations