MedTrace Logo

Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation

NCT06799260 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-06-25

No results posted yet for this study

Summary

Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols. Among these, intermittent- and continuous-theta burst stimulation (iTBS/cTBS) are increasingly used protocols to enhance or suppress M1 excitability, respectively, beyond stimulation. However, the poor reproducibility and high inter-individual variability in responses to TBS protocols are matters of concern. This study will explore whether ketone monoester supplementation can boost TBS efficacy via their mechanistic convergence on Brain-Derived Neurotrophic Factor (BDNF).

Conditions

  • Healthy Young Adult
  • Neurophysiology

Interventions

DIETARY_SUPPLEMENT

Ketone Monoester (KME)

500 mg/kg body weight of the KME supplement

DIETARY_SUPPLEMENT

Placebo

Taste-matched placebo drink

DEVICE

iTBS

iTBS stimulation will be applied using a butterfly figure-of-eight Cool-B70 coil connected to a MagPro R30 stimulator with add-on Theta Burst option (MagVenture A/S, Farum, Denmark).

DEVICE

cTBS

cTBS stimulation will be applied using a butterfly figure-of-eight Cool-B70 coil connected to a MagPro R30 stimulator with add-on Theta Burst option (MagVenture A/S, Farum, Denmark).

Sponsors & Collaborators

  • University of Oxford

    collaborator OTHER

  • Universiti Putra Malaysia

    lead OTHER

Principal Investigators

  • Wan Aliaa Wan Sulaiman, FRCP · Universiti Putra Malaysia

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-12-18
Primary Completion
2025-07-01
Completion
2025-12-01

Countries

  • Malaysia

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06799260 on ClinicalTrials.gov