MedTrace Logo

An Evaluation of Dose-escalation for Intrathoracic Tumours

NCT06794125 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 141

Last updated 2026-02-04

No results posted yet for this study

Summary

This is a pragmatic trial with patients randomized between standard of care palliative thoracic radiation therapy (RT) vs. hypofractionated, dose-escalated, esophageal-sparing (HD-ES) intensity modulated radiation therapy (IMRT).

The investigators hypothesize that the use of advanced radiation planning techniques to optimize dose to esophagus will permit the safe delivery of a modestly dose-escalated five-fraction course of palliative radiation to intrathoracic malignancies. This approach aims to deliver higher biologically effective doses while improving toxicity when compared to conventional approaches with the goal of prolonging high-quality overall survival.

Conditions

Interventions

RADIATION

Hypofractionated Radiation Therapy

Hypofractionated, dose-escalated, esophageal-sparing intensity modulated radiation therapy

RADIATION

Radiation Therapy

standard of care palliative thoracic radiotherapy using volumetric modulated arc therapy/intensity-modulating radiotherapy

Sponsors & Collaborators

  • Chris Goodman

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-03
Primary Completion
2029-03-01
Completion
2029-03-01

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06794125 on ClinicalTrials.gov