Sintilimab and Linperlisib Combination Treatment in Relapsed or Refractory Extranodal Natural Killer/T Cell Lymphoma
NCT06793956 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 12
Last updated 2025-03-13
Summary
This is an open-label, phase Ib study evaluating the combination treatment of sintilimab and linperlisib in patients with relapsed or refractory extranodal natural killer/T-cell lymphoma (NKTCL).
Conditions
- Extranodal Natural Killer/T Cell Lymphoma
Interventions
- DRUG
-
Sintilimab and Linperlisib Combination Treatment
Sintilimab administered via intravenous infusion; Linperlisib administered orally.
Sponsors & Collaborators
-
Sun Yat-sen University
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-02-21
- Primary Completion
- 2026-01-31
- Completion
- 2030-01-31
Countries
- China
Study Locations
More Related Trials
-
Sintilimab Plus R-CHOP as the First-line Treatment in Patients With Diffuse Large B-Cell Lymphoma.
NCT04023916 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study to Assess the Clinical Efficacy and Safety of Daratumumab in Participants With Relapsed or Refractory Natural Killer/T-Cell Lymphoma (NKTCL), Nasal Type
NCT02927925 ·Status: COMPLETED ·Phase: PHASE2
-
Sintilimab in Combination With R-CHOP in Patients With Treatment-naive EBV-positive DLBCL, NOS
NCT04181489 ·Status: UNKNOWN ·Phase: PHASE2
-
Orelabrutinib Plus Rituximab Followed by Maintenance With Orelabrutinib for Relapsed and Refractory Follicular Lymphoma(RR FL)
NCT04989621 ·Status: RECRUITING ·Phase: PHASE2
-
Linperlisib Combined With EZH2 Inhibitor in Relapsed/Refractory Peripheral T-cell Lymphoma (PTCL)
NCT06712173 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A National Multicenter, Real-world Study of Linperlisib in the Treatment of Lymphoma
NCT06343935 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Tislelizumab Combined with Mitoxantrone Hydrochloride Liposome in Extranodal Natural Killer/T Cell Lymphoma
NCT05464433 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Linperlisib in Combination With CHOP in Previously Untreated Peripheral T-Cell Lymphoma
NCT05949944 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Efficacy and Safety of IBI110 Single Agent and in Combination With Sintilimab in Patients With Relapsed or Refractory Diffuse Large B Cell Lymphoma (r/r DLBCL)
NCT05039658 ·Status: UNKNOWN ·Phase: PHASE1
-
Chidamide Combination With Lenalidomide in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma
NCT04329130 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Zimberelimab(GLS-010) Combined With AVD for Newly Diagnosed Early-stage Hodgkin's Lymphoma
NCT05900765 ·Status: RECRUITING ·Phase: PHASE2
-
Sintilimab Combined With Chidamide in Treating Peripheral T Cell Lymphoma
NCT04512534 ·Status: RECRUITING ·Phase: PHASE2
-
SHR-1210 in Patients With Relapsed or Refractory Extranodal NK/T Cell Lymphoma
NCT03363555 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of BGB-A317 in Participants With Relapsed or Refractory Mature T- and NK-cell Neoplasms
NCT03493451 ·Status: COMPLETED ·Phase: PHASE2
-
Sintilimab With P-GEMOX Versus the P-GEMOX in the Teatment of Advanced-stage Extranodal Natural Killer/T Cell Lymphoma
NCT06583083 ·Status: RECRUITING ·Phase: PHASE2
-
A Phase II Study of Rituximab, Chidamide, Zanubrutinib-induced and CHOP Therapy
NCT05527912 ·Status: UNKNOWN ·Phase: PHASE2
-
EZH2 Inhibitor Zeprumetostat in Combination Therapy for Patients With Relapsed or Refractory Mature T-cell and NK-cell Lymphomas
NCT07339527 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Anti-PD-1 Antibody Plus Chidamide and Rituximab Regimen in Relapsed or Refractory DLBCL (PCR)
NCT05115409 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Isatuximab and Cemiplimab in Relapsed or Refractory Natural Killer/T-cell Lymphoid Malignancy
NCT04763616 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Orelabrutinib in Combination With Gemox in Refractory / Relapsed Diffuse Large B-cell Lymphoma
NCT05381506 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Tofacitinib Combined With Chidamide in R/R ENKTCL
NCT03598959 ·Status: UNKNOWN ·Phase: PHASE2
-
Linperlisib-based Treatment Regimen in Newly Diagnosed Nodal T-follicular Helper Cell Lymphoma (nTFHL)
NCT06347653 ·Status: RECRUITING ·Phase: PHASE2
-
Linperlisib Plus Obinutuzumab and Venetoclax for Relapsed and Refractory Blastoid Variant of Mantle Cell Lymphoma.
NCT06324994 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Trial to Compare Ibrutinib Versus Lenalidomide in Combination With MRE-chemotherapy for Adult Patients With Recurrent/Refractory Primary Central Nervous System Lymphoma (PCNSL)
NCT04129710 ·Status: RECRUITING ·Phase: PHASE2
-
Golidocitinib Combined With Mitoxantrone Hydrochloride Liposome or Chidamide in the Treatment of Relapsed or Refractory Peripheral T-cell Lymphoma
NCT07093710 ·Status: RECRUITING ·Phase: PHASE1/PHASE2