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A Study of Enalapril in Treatment of Venous Malformations

NCT06788314 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2025-04-02

No results posted yet for this study

Summary

The goal of this clinical trial is to explore if enalapril can be used to treat painful venous malformations. The main question it aims to answer are:

\- Can enalapril reduce pain and volume of the malformation and increase quality of life in patients with painful venous malformations?

Participants will:

Receive a dose of enalapril 5 mg once daily. If it doesn't have effect the dose of enalapril will be increased to 10 mg daily after 3 months.

The treatment duration will be 12 months, with an additional follow-up of 12 months.

The visit frequency will be after 1, 3, 6,9 and 12 months and then a follow up visit at 18 and 24 months.

Approximately 15 participants will be screened to achieve minimum 10 enrolled participants.

Conditions

  • Venous Malformation
  • Pain
  • Quality of Life
  • Vascular Malformation

Interventions

DRUG

Enalapril

Each participant will receive a dose of enalapril 5 mg once daily. If the participant doesn't have effect of the intervention after 3 months, the dose of enalapril will be increased to 10 mg daily, if the tolerance of enalapril is good. Lack of effect will be defined as unchanged or increased NRS score. Treatment duration will be 12 months.

Sponsors & Collaborators

  • Oslo University Hospital

    lead OTHER

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-01
Primary Completion
2029-12-01
Completion
2030-12-01

Countries

  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06788314 on ClinicalTrials.gov