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"Xijiang Project" Screening Cohort for NPC

NCT06787456 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000000

Last updated 2025-01-22

No results posted yet for this study

Summary

The purpose of this study is to establish a comprehensive and integrated nasopharyngeal carcinoma screening cohort, which includes an epidemiological information database containing basic information, gender, age, ethnic and family history, dietary and lifestyle habits, and geographical environmental factors; a biobank of blood, tissue fluid, swabs, etc., for Epstein-Barr virus, tumors, and genetics; a clinical examination database including nasopharyngoscopy, imaging, pathology, and other examinations; and databases of Epstein-Barr virus and human genetic sequencing, etc.

Conditions

  • Nasopharyngeal Carcinoma (NPC)
  • Screening

Interventions

DIAGNOSTIC_TEST

EBV antibodies test

ELISA test of VCA-IgA, EBNA1-IgA, EA-IgA, Zta-IgA, Rta-IgG and P85-Ab in nasopharyngeal brushing and plasma in plasma, saliva and nasopharyngeal brushing.

DIAGNOSTIC_TEST

EBV DNA test

quantitative polymerase chain reaction, methylation sequencing and target sequencing of EBV DNA in nasopharyngeal brushing, saliva and plasma.

OTHER

epidemiological information survey

epidemiological information survey including basic conditions, dietary and lifestyle habits, social, geographical, environmental, and other information.

OTHER

Clinical examinations for high-risk participants

nasopharyngoscopy, head and neck MRI.

OTHER

EBV and human genetic sequencing

EB virus and human genetic sequencing for plasma, etc.

Sponsors & Collaborators

  • Fifth Affiliated Hospital, Sun Yat-Sen University

    collaborator OTHER

  • Sun Yat-sen University

    collaborator OTHER

  • Ming-Yuan Chen

    lead OTHER

Principal Investigators

  • Ming-yuan Chen, MD, PhD · Sun Yat-sen University

Eligibility

Min Age
30 Years
Max Age
69 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-11-14
Primary Completion
2035-12-31
Completion
2045-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06787456 on ClinicalTrials.gov