Timing of Carbetocin Administration in Postpartum Hemorrhage
NCT06776926 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200
Last updated 2025-09-18
Summary
Postpartum haemorrhage (PPH) is one of the major contributors to maternal mortality and morbidity worldwide. Active management of the third stage of labour has been proven to be effective in the prevention of PPH. Syntometrine is more effective than oxytocin but is associated with more side effects. Carbetocin, a long-acting oxytocin agonist, appears to be a promising agent for the prevention of PPH. The use of carbetocin, being an important agent in the prevention of PPH, also increases its prevalence. It is planned to investigate the advantages and disadvantages of the timing of its use.
Conditions
- Postpartum Hemorrhage
- Carbetocin
Interventions
- BEHAVIORAL
-
Carbetocin
Use of carbetocin
Sponsors & Collaborators
-
Mehmet Mete Kırlangıç
lead OTHER_GOV
Study Design
- Allocation
- RANDOMIZED
- Purpose
- DIAGNOSTIC
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 40 Years
- Sex
- FEMALE
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2025-01-10
- Primary Completion
- 2025-02-28
- Completion
- 2025-02-28
Countries
- Turkey (Türkiye)
Study Locations
More Related Trials
-
Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial
NCT02303418 ·Status: UNKNOWN ·Phase: PHASE3
-
Carbetocin at Elective Cesarean Delivery Part 2
NCT01428817 ·Status: COMPLETED ·Phase: NA
-
Carbetocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With BMI ≥ 40kg/m2
NCT03672045 ·Status: COMPLETED ·Phase: NA
-
Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Delivered Vaginally With at Least 2 Risk Factors for Atonic PPH: A Randomised Controlled Trial
NCT02304042 ·Status: COMPLETED ·Phase: PHASE3
-
Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia
NCT01382732 ·Status: UNKNOWN ·Phase: PHASE3
-
Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
NCT06333340 ·Status: RECRUITING ·Phase: NA
-
Carbetocin Versus Oxytocin in the Management of Atonic Post Partum Haemorrhage (PPH) in Women Delivered Vaginally: A Randomised Controlled Trial
NCT02304055 ·Status: COMPLETED ·Phase: PHASE3
-
Carbetocin Versus Ergometrine in the Management of Atonic Post Partum Haemorrhage (PPH) in Women Delivered Vaginally
NCT02410759 ·Status: UNKNOWN ·Phase: PHASE3
-
Carbetocin Versus Oxytocin for Prophylaxis Against Atonic Primary Post-partum Hemorrhage
NCT05479357 ·Status: UNKNOWN ·Phase: NA
-
Prophylactic Regimen of Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative for Primary Prevention of Postpartum Hemorrhage in Intrapartum Cesarean Section Versus Intravenous Carbetocin Alone
NCT07318467 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Oxytocin vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity
NCT04902729 ·Status: COMPLETED ·Phase: NA
-
Carbetocin vs. Oxytocin: In-vitro Myometrial Contractions With and Without Oxytocin Pre-treatment
NCT01689298 ·Status: COMPLETED ·Phase: NA
-
Carbetocin at Cesarean Delivery for Labor Arrest
NCT01725243 ·Status: COMPLETED ·Phase: NA
-
Intraumbilical Vein Injection of Oxytocin in Routine Practice for Active Management of the Third Stage of Labor
NCT01094028 ·Status: COMPLETED ·Phase: PHASE3
-
Protocols for Prevention of PPH During CS in High Risk Group
NCT05099575 ·Status: UNKNOWN
-
Intramuscular Oxytocics: A Randomised Control Trial
NCT02216383 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium
NCT06930391 ·Status: RECRUITING ·Phase: NA
-
When and How to Administer Oxytocin for Active Management of Third Stage of Labour
NCT01954186 ·Status: COMPLETED ·Phase: NA
-
Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium
NCT06285409 ·Status: RECRUITING ·Phase: NA
-
Carbetocin Versus Syntometrine for the Third Stage of Labour
NCT00499005 ·Status: COMPLETED ·Phase: PHASE4
-
Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony, During Elective Cesarean Section
NCT01630187 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Co-administration of Carbetocin and Calcium Chloride on Uterine Tone in Patients Undergoing Elective Cesarean Delivery
NCT07187544 ·Status: RECRUITING ·Phase: NA
-
Carbetocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy.
NCT04182360 ·Status: COMPLETED ·Phase: NA
-
IV vs IM Oxytocin in the Third Stage of Labor for Prevention of Postpartum Hemorrhage
NCT01608958 ·Status: COMPLETED ·Phase: NA
-
Intramuscular Versus Intravenous Prophylactic Oxytocin for Hemorrhage After Vaginal Delivery
NCT02080104 ·Status: UNKNOWN ·Phase: NA