Longitudinal Data Registry of Plasma Cell Dyscrasia

Summary

The goal of this multicenter observational study is to better understand the clinical and molecular characteristics, disease progression, treatment response, and clinical outcomes of patients with plasma cell dyscrasias, including monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, and light-chain amyloidosis. The study is led by Zhongshan Hospital, Fudan University, in collaboration with 18 other research centers in China. The main questions it aims to answer are:

Which clinical, laboratory, pathological, immunologic, cytogenetic, and genomic characteristics are associated with disease progression, treatment response, and patient outcomes? How do plasma cell dyscrasias and their underlying clones evolve over time? Can clinical and molecular information be used to develop models that predict disease progression and patient outcomes?

Researchers will collect and analyze historical and prospective clinical data from participating centers and follow patients over time. Participants' clinical course, laboratory and other test results, treatments, disease progression, and outcomes will be recorded and analyzed. This is an observational study and does not assign participants to any specific treatment.

Conditions

• Multiple Myeloma and Other Plasma Cell Neoplasms

Sponsors & Collaborators

• Tongji Hospital

  collaborator OTHER

• Peking University First Hospital

  collaborator OTHER

• The First Affiliated Hospital with Nanjing Medical University

  collaborator OTHER

• Zhongshan Hospital Xiamen University

  collaborator OTHER

• First Affiliated Hospital of Wenzhou Medical University

  collaborator OTHER

• Sir Run Run Shaw Hospital

  collaborator OTHER

• Zhangzhou Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• Huzhou Central Hospital, Affiliated Central Hospital HuZhou University

  collaborator UNKNOWN

• Huadong Hospital

  collaborator OTHER

• Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

  collaborator OTHER

• The Third Affiliated Hospital of Nanjing Medical University

  collaborator OTHER

• Peking University Shenzhen Hospital

  collaborator OTHER

• Zhejiang Provincial Tongde Hospital

  collaborator OTHER

• Shenzhen People's Hospital (the Second Clinical Medical College, Jinan University

  collaborator UNKNOWN

• Shanghai Geriatric Medical Center (Zhongshan Hospital Fudan University Minhang Campus)

  collaborator UNKNOWN

• The First Affiliated Hospital, Fujian Medical University

  collaborator UNKNOWN

• Guangdong Provincial People's Hospital

  collaborator OTHER

• Shanghai Zhongshan Hospital

  lead OTHER

Eligibility

Min Age

19 Years

Max Age

99 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-03-01

Primary Completion

2027-12-31

Completion

2028-12-31

Countries

• China

Study Locations