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Innovative Multidisciplinary Strategies for Combating Severe Dengue

NCT06751836 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1400

Last updated 2025-02-10

No results posted yet for this study

Summary

The goal of this observational study is to identify biomarkers and host factors associated with dengue severity in patients from dengue-endemic regions. The main question it aims to answer is:

Can multi-omics approaches predict disease severity and identify key factors contributing to severe dengue infections?

Participants will include individuals with dengue infection, and the study will analyze their blood samples using multi-omics techniques to uncover host immune responses, disease pathogenesis, and cellular pathway interactions. The study will also assess the role of primary and secondary infections, virus serotypes, and immunological factors in disease progression. Findings aim to support disease management, improve severity prediction, and identify potential therapeutic targets to prevent severe outcomes.

Conditions

  • DENV Without Warning Signs
  • DENV with Warning Signs
  • Severe Dengue
  • Healthy Controls Group - Age and Sex-matched

Interventions

OTHER

Infection and no infection

No intervention apart from the dengue infection

Sponsors & Collaborators

  • BIO BOX GUATEMALA ONG DE INVESTIGACIÓN, SERVICIOS Y DE MEDIO AMBIENTE

    collaborator UNKNOWN

  • DEVKI DEVI FOUNDATION SOCIETY, India

    collaborator UNKNOWN

  • MANIPAL ACADEMY OF HIGHER EDUCATION, India

    collaborator UNKNOWN

  • Artemis Medicare Services Ltd., India

    collaborator UNKNOWN

  • Karolinska Institutet

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-03
Primary Completion
2026-12-31
Completion
2029-10-31

Countries

  • Guatemala
  • India

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06751836 on ClinicalTrials.gov