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Ex-vivo Hypotermic Perfusion in Patients with Hepatocellular Carcinoma to Reduce the Incidence of Tumor Recurrence

NCT06720675 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 237

Last updated 2025-01-30

No results posted yet for this study

Summary

This is a retrospective study of single-center cohorts that involves patients with HCC who underwent liver transplantation between January 2016 and 2021, who received livers preserved with Hypothermic Oxygenated Perfusion (HOPE) or Static Cold Storage (SCS) with a minum follow up of 12 months.

Conditions

  • Liver Carcinoma
  • Liver Transplant
  • Tumor Recurrence
  • Hepato Cellular Carcinoma (HCC)
  • Hypothermic Oxygenated Machine Perfusion

Interventions

PROCEDURE

Hypothermic Oxygented Perfusion

HOPE start by flushing the organ at low flow values (30 ml/min) with new oxygenated perfusion fluid (cold Belzer MPS solution) during back-table preparation. Hepatic perfusion was performed through the vein leads to a pressure of 3-5 mmHg. Organ were treated with continuous HOPE until transplant and the perfusion was continuously monitored and data downloaded in a USB memory.

PROCEDURE

Static Cold Storage

Liver grafts are stored in sterile organ bags with cold Belzer or Celsior solution and kept in ice at 4°C.

Sponsors & Collaborators

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna

    lead OTHER

Principal Investigators

  • Matteo Ravaioli, MD · IRCCS Azienda Ospedaliero-Universitaria di Bologna

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-03
Primary Completion
2024-01-08
Completion
2024-01-08

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06720675 on ClinicalTrials.gov