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tFUS for Memory in mNCD and Healthy Adults

NCT06718140 · Status: ENROLLING_BY_INVITATION · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2025-11-24

No results posted yet for this study

Summary

Dementia is an ongoing and growing public health crisis in the US and worldwide. The purpose of this study is to examine a form of noninvasive brain stimulation called transcranial focused ultrasound (tFUS) to the hippocampus with the goal of improving memory.

Conditions

  • Mild Neurocognitive Disorder
  • Healthy Aging

Interventions

DEVICE

Transcranial Focused Ultrasound

Using MRI-guided targeting, we will administer focused ultrasound to one of the 4 brain locations

Sponsors & Collaborators

  • National Center of Neuromodulation for Rehabilitation

    collaborator OTHER

  • Medical University of South Carolina

    lead OTHER

Principal Investigators

  • Kevin Caulfield, PhD · Medical University of South Carolina

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
50 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-30
Primary Completion
2026-12-01
Completion
2027-12-01
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06718140 on ClinicalTrials.gov