PK/PD Relationship of CAZ/AVI and FOS in the Treatment of Patients With Infections Due to CRE
NCT06717594 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 60
Last updated 2025-11-28
Summary
A multicenter international prospective observational pharmacological study in adult patients (≥18 years) treated with ceftazidime/avibactam (CAZ/AVI) alone or with CAZ/AVI plus fosfomycin (FOS) for infection due to carbapenem-resistant Enterobacterales (CRE) (KPC and/or OXA-48).
Conditions
- Gram Negative Infections
- Antimicrobial Resistance (AMR)
Sponsors & Collaborators
-
IRCCS Azienda Ospedaliero-Universitaria di Bologna
lead OTHER
Principal Investigators
-
Maddalena Giannella, MD PhD · IRCCS Azienda Ospedaliero-Universitaria di Bologna
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-12-01
- Primary Completion
- 2026-04-30
- Completion
- 2026-04-30
Countries
- Italy
- Spain
Study Locations
More Related Trials
-
Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections)
NCT01599806 ·Status: COMPLETED ·Phase: PHASE3
-
Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis
NCT01345929 ·Status: COMPLETED ·Phase: PHASE3
-
Reporting Patterns and Results of Initial Antibiotic Treatment in Patients With cUTI, cIAI,NP Including VAP
NCT02364284 ·Status: COMPLETED
-
GSK2251052 in the Treatment of Complicated Intra-abdominal Infections
NCT01381562 ·Status: TERMINATED ·Phase: PHASE2
-
Compare Ceftazidime-Avibactam + Metronidazole Versus Meropenem for Hospitalized Adults With Complicated Intra-Abdominal Infections
NCT01499290 ·Status: COMPLETED ·Phase: PHASE3
-
Prospective Multicenter Doubleblind Randomized Study of NXL104/Ceftazidime + Metronidazole vs. Meropenem in Treatment of Complicated Intra-abdominal Infections
NCT00752219 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
NCT04882085 ·Status: COMPLETED ·Phase: PHASE4
-
Impact of Ceftazidime / Avibactam Treatment vs Better Available Therapy on Mortality of Patients With Infections Caused by Carbapenem-resistant Enterobacteria
NCT04167228 ·Status: COMPLETED
-
Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae
NCT04516395 ·Status: UNKNOWN ·Phase: NA
-
Outcomes of Empiric Antibiotic Therapy Based on Hospital Antibiograms in Organ Transplant Recipients with Bacteraemia
NCT06874920 ·Status: ENROLLING_BY_INVITATION
-
Relationship Between Different Administration Regimens of Ceftazidime/Avibactam and Clinical Outcomes
NCT06528028 ·Status: RECRUITING ·Phase: PHASE4
-
Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to ESBL- or Carbapenemase-producing Enterobacterales in Solid Organ Transplantation: an Observational Multinational Study.
NCT02852902 ·Status: COMPLETED
-
Compare Ceftazidime-Avibactam + Metronidazole vs Meropenem for Hospitalized Adults With Complicated Intra-Abd Infections
NCT01726023 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Treatment for Enterococcus Faecalis Bacteriemia Multicenter, Observational Study"
NCT04070820 ·Status: UNKNOWN
-
Emergence of Resistance in Intestinal Microflora During Carbapenem Treatments
NCT01703299 ·Status: COMPLETED
-
Mortality of MBL-producing Enterobacteriaceae Bacteremias with the Combined Use of Ceftazidime-avibactam and Aztreonam Vs. Other Active Antibiotics. a Multicenter Target Trial Emulation.
NCT06419296 ·Status: COMPLETED
-
Short vs Long of Usual Treatment for Non Complicated Enterococcal Bacteremia
NCT05394298 ·Status: UNKNOWN ·Phase: PHASE4
-
Deescalating Carbapenems in Hospital Setting
NCT02265445 ·Status: TERMINATED ·Phase: PHASE4
-
Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to Extended-spectrum Beta-lactamase (ESBL) or Carbapenemase-producing Enterobacteriaceae: an Observational Multinational Study
NCT01764490 ·Status: COMPLETED
-
Impact of a TDM-guided ECPA Program for Optimizing Pharmacodynamic Target Attainment of Continuous Infusion Beta-lactam-based Regimen
NCT06718517 ·Status: RECRUITING
-
Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae
NCT02420366 ·Status: COMPLETED
-
Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae
NCT02795949 ·Status: COMPLETED ·Phase: PHASE3
-
Study Comparing Tigecycline to Imipenem/Cilastatin in Complicated Intra-Abdominal Infections in Hospitalized Subjects
NCT00081744 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli
NCT01820793 ·Status: TERMINATED ·Phase: NA
-
Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI)
NCT00230971 ·Status: COMPLETED ·Phase: PHASE4