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Artificial Intelligence-based Models for Spine Malalignment Auto-analysis

NCT06711757 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 3015

Last updated 2024-12-02

No results posted yet for this study

Summary

This retrospective study aimed to enhance and validate a model for diagnosing adolescent idiopathic scoliosis (AIS) across multiple medical centers. The study included 2,763 participants from prestigious hospitals in mainland China and Hong Kong. X-rays were used to develop and validate the model, with data from different hospitals to ensure robustness. Participants aged 10-18 with confirmed AIS were enrolled, and data were deidentified for privacy. The model was optimized using training data and validated internally before being deployed for real-world application. A novel data augmentation technique was used to address data heterogeneity, and a standardized analysis platform, AlignProCARE, was employed for evaluation. X-rays were annotated with vertebra landmarks, and traditional and intensity-based data augmentation methods were applied for image processing. Coronal Cobb angle was used to evaluate spinal alignment, with severity classified as normal-mild, moderate, or severe. The model's performance was statistically assessed for accuracy in predicting Cobb angle and severity grading. Overall, the study aimed to provide a reliable diagnostic tool for AIS analysis in clinical practice, improving efficiency and standardization in diagnosis and treatment.

Conditions

  • Adolescent Idiopathic Scoliosis

Sponsors & Collaborators

  • Peking Union Medical College Hospital

    collaborator OTHER

  • Queen Mary Hospital, Hong Kong

    collaborator OTHER

  • The Duchess of Kent Children's Hospital at Sandy Bay

    collaborator UNKNOWN

  • Ruijin Hospital

    collaborator OTHER

  • Huashan Hospital

    collaborator OTHER

  • Beijing Jishuitan Hospital

    collaborator OTHER

  • Nanfang Hospital, Southern Medical University

    collaborator OTHER

  • The University of Hong Kong

    lead OTHER

Eligibility

Min Age
10 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-05
Primary Completion
2024-10-05
Completion
2024-11-05

Countries

  • Hong Kong

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06711757 on ClinicalTrials.gov