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Emergency Total ECLS vs Standard ACLS With ECMO Bailout for Survival in Refractory OHCA

NCT06692075 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 332

Last updated 2025-05-18

No results posted yet for this study

Summary

The goal of the clinical trial is to learn if early extracorporeal life support ( ECLS ) will save more out-of-hospital cardiac arrest ( OHCA ) patients with good neurological outcome. It will also learn if emergency ECLS is safe in the OHCA rescue. Researchers aim to investigate if emergency total ECLS is better than standard advanced cardiac life support ( ACLS ) first, followed by bailout ECMO if required, for survival with favorable neurological outcome in OHCA patients. Participants meeting criteria of OHCA with witness, bystander CPR, shockable initial rhythm with repeated defibrillation, and transport time less than 30 min will be compared between total ECLS versus standard ACLS first with bailout ECMO protocols. All participants will receive emergency interventional coronary revascularization , intensive care unit therapy , cardiac ward care and up to 180 days of clinical follow up after survival .

Conditions

  • Out-of-hospital Cardiac Arrest (OHCA)

Interventions

PROCEDURE

extracorporeal life support

ECMO supported life support for cardiopulmonary resuscitation in refractory OHCA

PROCEDURE

standard ACLS

Standard ACLS in cardioplumonary resuscitation of refractory OHCA

Sponsors & Collaborators

  • Taipei Medical University Shuang Ho Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-11-01
Primary Completion
2027-11-30
Completion
2027-11-30

Countries

  • Taiwan

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06692075 on ClinicalTrials.gov