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Different Treatment Modalities for Oral Lichen Plan

NCT06681090 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-02-07

No results posted yet for this study

Summary

The goal of applications of Low-Level Laser and Topical Steroid in the Management of Oral Lichen Planus is to learn if intervention can by relieve pain, decreasing inflammation, and facilitating tissue healing in20 patients who were suffering from erosive oral lichen planus. The main questions it aims to answer are which is better and more effective as treatment modality. The erosion size (mm2) measured on the first day and 4 weeks later. Oral Health-Related Quality of Life questionnaire manipulated. Researchers will take Low-Level Laser and Topical Steroid in the Management of Oral Lichen Planus to see if it could be used as separate treatment option or as combination.

Conditions

  • Oral Lichen Planus

Interventions

DRUG

0.1% topical triamcinolone Acetonide preparation "Kenacourt-A Orabase"

The patients were administered topical corticosteroids in the form of a 0.1% triamcinolone acetonide preparation (Kenacort TM 0.1% Abbott). The medication was to be used 3 times every day for 4 weeks or until the lesion has healed, whichever occurs first. After applying the gel, the patients were instructed not to consume any fluids or food for at least 1 hour. In addition, a topical antifungal treatment consisting of Miconazole oral gel at a concentration of 2% should be applied once a day for 4 weeks

DEVICE

980 nm diode laser

First group (Group A) underwent PBM therapy using a 980 nm diode laser (elexxion nano dental laser with a flat top handpiece). The therapy included 8 sessions for 4 weeks, with 2 sessions conducted per week, all administered by the same operator. The energy was evenly distributed across all the mucosal lesions and the surrounding tissues within a 0.5 cm range using a spot-technique method with little overlap.

Sponsors & Collaborators

  • Assiut University

    collaborator OTHER

  • Al-Azhar University

    lead OTHER

Principal Investigators

  • Ahmed F. Assistant Professor, PhD · Faculty of Dentistry, Assiut University, Egypt

  • Rahma M. Lecturer, PhD · Faculty of Dentistry, Assiut University, Egypt

  • Asem K. Lecturer, PhD · Dental Medicine Faculty, Al-Azhar University (Assiut Branch), Assiut, Egypt

  • Mahmoud A. Professor, PhD · Faculty of Dentistry, Al-Azhar University (Assiut Branch), Assiut, Egypt.

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-03
Primary Completion
2023-09-25
Completion
2023-10-29

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06681090 on ClinicalTrials.gov