Lusutrombopag Combined With Recombinant Human Thrombopoietin for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Destined to Undergo Elective Invasive Surgery
NCT06673498 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2024-11-05
Summary
To assess the efficacy and safety of lusutrombopag combined with recombinant human thrombopoietin for the treatment of thrombocytopenia in patients with chronic liver disease destined to undergo elective invasive surgery.
Conditions
Interventions
- DRUG
-
Lusutrombopag combined with recombinant human thrombopoietin
After eligibility is confirmed, patients will begin treatment with Lusutrombopag +recombinant human thrombopoietin on Day 1, and study treatment will continue for 7 days
Sponsors & Collaborators
-
Anhui Provincial Hospital
lead OTHER_GOV
Principal Investigators
-
Lianxin Liu · Anhui Provincial Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-11-10
- Primary Completion
- 2025-11-30
- Completion
- 2025-11-30
Countries
- China
Study Locations
More Related Trials
-
A Phase Ib Clinical Study for rhTPO in the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease
NCT05193201 ·Status: UNKNOWN ·Phase: PHASE1
-
The Tolerability,Safety,PK/PD Study of rhTPO in the Patients With Liver Function Impairment
NCT03673215 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
An Open-label Safety Study of Lusutrombopag (S-888711) in Adults With Chronic Immune Thrombocytopenia (ITP)
NCT01129024 ·Status: TERMINATED ·Phase: PHASE2
-
Study on the Efficacy and Safety of Avatricopal in Patients With CLD Complicated With Thrombocytopenia
NCT06642740 ·Status: ENROLLING_BY_INVITATION
-
Eltrombopag To Reduce The Need For Platelet Transfusion In Subjects With Chronic Liver Disease And Thrombocytopenia Undergoing Elective Invasive Procedures
NCT00678587 ·Status: TERMINATED ·Phase: PHASE3
-
A Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of MegaLT Injection for Treating Refractory Thrombocytopenia Following Radiotherapy, Chemotherapy, or Transplantation.
NCT06534255 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Avatrombopag to Promote Platelet Engraftment After Allo-HSCT
NCT05143892 ·Status: UNKNOWN ·Phase: PHASE2
-
Once-Daily Oral Avatrombopag Tablets Used in Subjects With Chronic Liver Diseases and Thrombocytopenia Prior to Elective Surgical or Diagnostic Procedures
NCT00914927 ·Status: COMPLETED ·Phase: PHASE2
-
A Clinical Study of Anfibatide in Acquired Thrombotic Thrombocytopenic Purpura (TTP)
NCT04021173 ·Status: UNKNOWN ·Phase: PHASE2
-
A Clinical Study of Herombopag in Tumors-associated Thrombocytopenia
NCT05350956 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of CM313(SC) Injection in Subjects With Platelet Transfusion Refractoriness
NCT06792019 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study to Investigate the Efficacy and Safety of Lusutrombopag (S-888711) Tablets Administered to Adults With Immune Thrombocytopenia (ITP)
NCT01054443 ·Status: TERMINATED ·Phase: PHASE2
-
A Trial of Hetrombopag in Healthy and Hepatic Impairment Subjects
NCT05088642 ·Status: COMPLETED ·Phase: PHASE1
-
Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing an Elective Procedure
NCT01976104 ·Status: COMPLETED ·Phase: PHASE3
-
Avatrombopag for the Treatment of Thrombocytopenia in Adults With Chronic Liver Disease Undergoing a Procedure
NCT03554759 ·Status: TERMINATED
-
Treatment of Thrombocytopenia in Patients With Chronic Liver DiseaseUndergoing an Elective Procedure
NCT01972529 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Once-daily Oral Avatrombopag in Japanese Subjects With Chronic Liver Diseases and Thrombocytopenia
NCT02227693 ·Status: COMPLETED ·Phase: PHASE2
-
Platelet Augmentation Using C. Papaya Leaf Extract in Live Donor Liver Transplantation
NCT05360134 ·Status: UNKNOWN ·Phase: NA
-
Efficacy and Safety of Avatrombopag Combined With IST for the Treatment of HAAA and SAA With Abnormal Liver Function
NCT05571332 ·Status: UNKNOWN ·Phase: NA
-
Avatrombopag for the Treatment of Thrombocytopenia in Adults Scheduled for a Surgical Procedure
NCT03326843 ·Status: TERMINATED ·Phase: PHASE3
-
Perioperative Eltrombopag in Patients With Inherited Thrombocytopenia
NCT03638817 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Study on Efficacy and Safety of Hetrombopag in the Preoperative Patients of Thrombocytopenia
NCT06562738 ·Status: RECRUITING ·Phase: PHASE4
-
Treatment of Polycythaemia Vera and Essential Thrombocythaemia: Influence on the Clot Structure
NCT02912884 ·Status: COMPLETED
-
Pharmacokinetic, Efficacy and Safety of BT524 in Patients With Congenital Fibrinogen Deficiency
NCT02065882 ·Status: COMPLETED ·Phase: PHASE3
-
to Evaluate the Efficacy and Safety of Eltrombopag for Immune Thrombocytopenia With Chronic HBV Infection
NCT03664518 ·Status: COMPLETED ·Phase: PHASE2