HPV Vaccine Integrated Service Implementation Research in Ethiopia

Summary

The goal of this implementation research study is to understand whether a package of community-based interventions can increase access to and uptake of the human papillomavirus (HPV) vaccine among very young adolescent girls in rural Ethiopia. The main questions this study aims to answer are:

* Can a package of community-based interventions increase delivery of routine HPV vaccination to girls aged 9-14 in rural Ethiopia?
* Is an intervention model that incorporates strategies that address gender norms and gender-specific barriers more effective at increasing delivery of routine HPV vaccination than a model that does not explicitly address gender?
* What is the acceptability, feasibility, cost, and potential for maintenance and scale of an integrated health intervention to delivery routine HPV vaccination in rural Ethiopia?

To evaluate the effectiveness of the intervention, researchers will compare HPV vaccination within regions where the new intervention model is being implemented (intervention areas) to regions where the new routine HPV vaccination delivery model is not being implemented (comparison areas) for approximately 1 year before the new intervention model is implemented and for approximately 1 year after the start of implementation to compare changes over time and between intervention and comparison areas.

The study will evaluate the effect of the intervention on HPV vaccination delivery using routine health facility data.

To understand acceptability, feasibility, implementation, and potential for scale, the study will enroll participants including health officials and providers, adolescents girls receiving HPV vaccination and other services in intervention areas, and their parents/caregivers.

These participants may be asked to participate in one or more of the following:

* Completing a short questionnaire after receiving health services, including HPV vaccination, and their knowledge and attitudes towards HPV vaccination and experiences of care
* Participating in an interview or a focus group discussion to discuss HPV vaccination services and the role of the intervention in delivering care

Conditions

• Papillomavirus Vaccines
• HPV Vaccines
• HPV Vaccine Acceptability
• HPV Vaccine Attitudes
• HPV Vaccinations
• HPV Vaccine Knowledge
• Adolescent Health
• Adolescent Health Services
• Integrated Community-based Intervention Package

Interventions

OTHER

Integrated health service delivery for very young adolescent girls

The proposed HPV-VISION intervention will aim to increase girl-centered access to HPV vaccination and other VYA services through an integrated, routine, community-based delivery model that incorporates household mobilization efforts with enhanced service delivery at the health post level.

Sponsors & Collaborators

• Addis Ababa University

  collaborator OTHER

• Federal Democratic Republic of Ethiopia Ministry of Health

  collaborator UNKNOWN

• Population Services International

  lead OTHER

Principal Investigators

• Wakgari Deressa, PhD MPH · College of Health Sciences, Addis Ababa University

Study Design

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

9 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-10-31

Primary Completion

2025-09-30

Completion

2026-03-31