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Monitoring Lupus Nephritis Through Urinary Extracellular Vesicles

NCT06642402 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2025-09-09

No results posted yet for this study

Summary

Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that can lead to irreversible kidney damage if not detected and managed promptly. LN is classified and treated based on its histopathological features obtained by invasive kidney biopsy. Recent research has suggested urinary extracellular vesicles (uEVs) as potential non-invasive biomarkers. The primary objective of this prospective study is to investigate the utility of uEVs in LN.

Conditions

  • Systemic Lupus Erythematosus Nephritis

Interventions

DIAGNOSTIC_TEST

Kidney biopsy

Patient refered to kidney biopsy independent of the presented study

DIAGNOSTIC_TEST

Urinary extracellular vesicle testing

Urinary extracellular vesicles will be isolated and tested for complement activation and other markers of kidney disease

DIAGNOSTIC_TEST

Autoimmunity in plasma

Expected autoimmunity in plasma isolated from blood samples

Sponsors & Collaborators

  • University of Southern Denmark

    collaborator OTHER

  • Odense University Hospital

    collaborator OTHER

  • Kolding Sygehus

    lead OTHER

Principal Investigators

  • Anne F Christensen, Chief of Medicine, MD, phd · Sygehus Lillebaelt, Kolding Hospitl

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-11-15
Primary Completion
2029-05-01
Completion
2030-05-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06642402 on ClinicalTrials.gov